Tetraspanin 9 Explained

Tetraspanin 9 is a protein that in humans is encoded by the TSPAN9 gene.^[1]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternatively spliced transcripts encoding the same protein have been identified. [provided by RefSeq, Nov 2009].

Further reading

• Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JM, Bicknell R, Senis YA, Ashman LK, Berditchevski F, Ouwehand WH, Watson SP, Tomlinson MG . Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains . Biochem. J. . 417 . 1 . 391–400 . 2009 . 18795891 . 2652832 . 10.1042/BJ20081126 .
• Kotha J, Zhang C, Longhurst CM, Lu Y, Jacobs J, Cheng Y, Jennings LK . Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia . Atherosclerosis . 203 . 2 . 377–86 . 2009 . 18799160 . 10.1016/j.atherosclerosis.2008.07.036 .
• Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC . Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease . Mol. Psychiatry . 14 . 11 . 1004–16 . 2009 . 19204726 . 2860783 . 10.1038/mp.2009.10 .
• Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y . Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals . Am. J. Hypertens. . 23 . 1 . 70–7 . 2010 . 19851296 . 10.1038/ajh.2009.190 . free .
• Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y . Association of genetic variants with hemorrhagic stroke in Japanese individuals . Int. J. Mol. Med. . 25 . 4 . 649–56 . 2010 . 20198315 . 10.3892/ijmm_00000388. free .
• Stiles KM, Kielian M . Role of TSPAN9 in Alphavirus Entry and Early Endosomes . J. Virol. . 90 . 9 . 4289–97 . 2016 . 26865714 . 4836341 . 10.1128/JVI.00018-16 .

Notes and References

1. Web site: Entrez Gene: Tetraspanin 9. 2017-11-30.