Tetraprenyl-beta-curcumene synthase explained

Tetraprenyl-β-curcumene synthase
Ec Number:	4.2.3.130

Tetraprenyl-β-curcumene synthase (EC 4.2.3.130, ytpB (gene)) is an enzyme with systematic name all-trans-heptaprenyl-diphosphate diphosphate-lyase (cyclizing, tetraprenyl-β-curcumene-forming).^[1] This enzyme catalyses the following chemical reaction

all-trans-heptaprenyl diphosphate

\rightleftharpoons

tetraprenyl-β-curcumene + diphosphate

This enzyme is isolated from Bacillus subtilis.

Notes and References

Sato T, Yoshida S, Hoshino H, Tanno M, Nakajima M, Hoshino T . Sesquarterpenes (C₃₅ terpenes) biosynthesized via the cyclization of a linear C₃₅ isoprenoid by a tetraprenyl-β-curcumene synthase and a tetraprenyl-β-curcumene cyclase: identification of a new terpene cyclase . Journal of the American Chemical Society . 133 . 25 . 9734–7 . June 2011 . 21627333 . 10.1021/ja203779h .