Tetrandrine Explained

Tetrandrine, a bis-benzylisoquinoline alkaloid, is a calcium channel blocker.[1] It is isolated from the plant Stephania tetrandra,[2] and other Chinese and Japanese herbs.

Pharmacology

It has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a quinidine-like anti-arrhythmic effect. It has vasodilatory properties and can therefore reduce blood pressure.[3] Tetrandrine may have potential use for the treatment of liver disease[4] and liver cancer.[5] [6] [7] Tetrandrine has potential therapeutic value to prevent excess scarring/fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation.[8] Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis.[9] Tetrandrine has also been shown to inhibit entry of Ebola virus into host cells in vitro and showed therapeutic efficacy against Ebola in preliminary studies on mice.[10] Tetrandrine has also been studied and patented as a possible treatment for tinnitus.[11] [12] [13]

Biosynthesis

Tetrandrine is biosynthesized from a free radical coupled dimerization of S-N-methylcoclaurine:[14]

Synonyms

Synonyms include fanchinine, hanfangchin A, NSC 77037, (S,S)-(+)-tetrandrine, sinomenine A, TTD, tetrandrin, d-tetrandrine, and GW-201.[15]

References

  1. Bhagya . N . Chandrashekar . KR . Tetrandrine – A molecule of wide bioactivity . Phytochemistry . 125 . 1 May 2016 . 0031-9422 . 10.1016/j.phytochem.2016.02.005 . 5–13 . 26899361 . 2016PChem.125....5B . 24 February 2022.
  2. 10.1002/jssc.200900413. Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae. 2009. Zhang. Lijin. Geng. Yanling. Duan. Wenjuan. Wang. Daijie. Fu. Maorun. Wang. Xiao. Journal of Separation Science. 32. 20. 3550–3554. 19764054.
  3. 12466042. 2002. Kwan. C. Y.. Achike. F. I.. Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: Cardiovascular effects and mechanisms of action. Acta Pharmacologica Sinica. 23. 12. 1057–68.
  4. 10.1016/j.imlet.2008.10.001. Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-κB activation. 2008. Feng. Dechun. Mei. Yunhua. Wang. Ying. Zhang. Bianhong. Wang. Chen. Xu. Lingyun. Immunology Letters. 121. 2. 127–133. 18992279.
  5. 10.1002/ijc.25817. Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. 2011. Liu. Chaoyang. Gong. Ke. Mao. Xin. Li. Wenhua. International Journal of Cancer. 129. 6. 1519–1531. 21128229. 3163935. free.
  6. 10.1016/j.phymed.2010.03.018. Proteomic analysis of anti-tumor effects by tetrandrine treatment in HepG2 cells. 2010. Cheng. Zhixiang. Wang. Keming. Wei. Jia. Lu. Xiang. Liu. Baorui. Phytomedicine. 17. 13. 1000–1005. 20554191.
  7. 19230406. 2008. Deng. W. Y.. Luo. S. X.. Zhou. M. Q.. Li. N.. Chen. X. B.. Han. L. L.. The study of anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials. 31. 10. 1522–5.
  8. 10.1080/02713680802220817. Tetrandrine Suppresses Activation of Human Subconjunctival Fibroblasts In Vitro. 2008. Kitano. Ai. Yamanaka. Osamu. Ikeda. Kazuo. Ishida-Nishikawa. Iku. Okada. Yuka. Shirai. Kumi. Saika. Shizuya. Current Eye Research. 33. 7. 559–565. 18600488. 37248080.
  9. 12466042. 2002. Kwan. C. Y.. Achike. F. I.. Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: Cardiovascular effects and mechanisms of action. Acta Pharmacologica Sinica. 23. 12. 1057–68.
  10. 10.1126/science.1258758. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment. 2015. Sakurai. Yasuteru. Kolokoltsov. Andrey A.. Chen. Cheng-Chang. Tidwell. Michael W.. Bauta. William E.. Klugbauer. Norbert. Grimm. Christian. Wahl-Schott. Christian. Biel. Martin. Davey. Robert A.. Science. 347. 6225. 995–998. 25722412. 4550587. 2015Sci...347..995S.
  11. US . 10434097 . patent . Methods and compositions for treating hearing disorders . 8 October 2019 . 2 February 2017 . Jianxin Bao . Xiaojie Chen . Gateway Biotechnology Inc.
  12. Web site: Targeting multiple signaling pathways for tinnitus prevention and treatment (R44DC018759) . HHS Tracking Accountability in Government Grants System (TAGGS) . US Department of Health & Human Services . 24 February 2022 . https://web.archive.org/web/20220224073007/https://taggs.hhs.gov/Detail/AwardDetail?arg_AwardNum=R44DC018759&arg_ProgOfficeCode=45 . 24 February 2022.
  13. Dyhrfjeld-Johnsen . Jonas . Cederroth . Christopher R. . Current Clinical Trials for Tinnitus . Otolaryngologic Clinics of North America . 53 . 4 . 1 August 2020 . 0030-6665 . 32334870 . 10.1016/j.otc.2020.03.012 . 651–666 . 216557264 . 24 February 2022.
  14. 10.1016/S0031-9422(00)91024-0. Biosynthesis of the bisbenzylisoquinoline alkaloid, tetrandrine. 1980. Bhakuni. Dewan S.. Jain. Sudha. Singh. Awadhesh N.. Phytochemistry. 19. 11. 2347–2350. 1980PChem..19.2347B.
  15. http://www.selleckchem.com/products/Tetrandrine-Fanchinine.html Tetrandrine(Fanchinine) CAS 518-34-3 calcium channel Inhibitor Fanchinine, Hanfangchin A, NSC 77037, S,S-(+)-Tetrandrine, Sinomenine A, TTD, Tetrandrin, d...

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tetrandrine".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.