Tetramethylazodicarboxamide Explained

Tetramethylazodicarboxamide (also known as TMAD and diamide) is a reagent used in biochemistry for oxidation of thiols in proteins to disulfides. It has also been used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate.

Further reading

• 10.1246/cl.1994.539 . N,N,N',N'-Tetramethylazodicarboxamide(TMAD), A New Versatile Reagent for Mitsunobu Reaction. Its Application to Synthesis of Secondary Amines . 1994 . Tsunoda . Tetsuto . Otsuka . Junko . Yamamiya . Yoshiko . Itô . Shô . Chemistry Letters . 539 . 3.