Tetrahydropapaveroline Explained

Tetrahydropapaveroline (norlaudanosoline) is a benzyltetrahydroisoquinoline alkaloid.^[1]

It can be formed in trace amounts in the brain by a condensation reaction of dopamine and dopaldehyde (a metabolite of dopamine).^{[1] [2]}

It inhibits dopamine uptake within the cerebral cortex.^[3]

Notes and References

1. Book: Richter. Derek. Addiction and Brain Damage. 14 October 2016. Routledge. 978-1-315-45403-0. 24. en.
2. Alcohol drinking: abnormal intake caused by tetrahydropapaveroline in brain . RD Myers . CL Melchior . Science . 29 April 1977 . 196 . 4289 . 554–556 . 10.1126/science.557839 . 557839 . 1977Sci...196..554M .
3. Okada . T. . Shimada . S. . Sato . K. . Kotake . Y. . Kawai . H. . Ohta . S. . Tohyama . M. . Nishimura . T. . January 1998 . Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells . Neuroscience Research . 30 . 1 . 87–90 . 10.1016/s0168-0102(97)00121-1 . 0168-0102 . 9572583.