Tetrahydrofuranylfentanyl Explained

Tetrahydrofuranylfentanyl is an opioid analgesic that is an analog of fentanyl and has been sold online as a designer drug, first appearing in Europe in late 2016.^{[1] [2]}

Side effects

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.^[3] A new wave of fentanyl analogues and associated deaths began in around 2014 in the US, and have continued to grow in prevalence; especially since 2016 these drugs have been responsible for hundreds of overdose deaths every week.^[4]

Legal status

Tetrahydrofuranylfentanyl was placed into Schedule I in the US in October 2017, in order to avoid an imminent hazard to public safety.^[5]

See also

• α-Methylfentanyl
• Acetylfentanyl
• Butyrfentanyl
• Furanylfentanyl
• List of fentanyl analogues

Notes and References

1. Web site: EMCDDA–Europol Joint Report on a new psychoactive substance: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]tetrahydrofuran-2-carboxamide (tetrahydrofuranylfentanyl; THF-F) ]. September 2017 .
2. Kanamori T, Segawa H, Yamamuro T, Kuwayama K, Tsujikawa K, Iwata YT . Metabolism of a new synthetic opioid tetrahydrofuranylfentanyl in fresh isolated human hepatocytes: Detection and confirmation of ring-opened metabolites . Drug Testing and Analysis . 12 . 4 . 439–448 . April 2020 . 31797567 . 10.1002/dta.2743 . 208627099 .
3. Mounteney J, Giraudon I, Denissov G, Griffiths P . Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe . The International Journal on Drug Policy . 26 . 7 . 626–631 . July 2015 . 25976511 . 10.1016/j.drugpo.2015.04.003 .
4. Armenian P, Vo KT, Barr-Walker J, Lynch KL . Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review . Neuropharmacology . 134 . Pt A . 121–132 . May 2018 . 29042317 . 10.1016/j.neuropharm.2017.10.016 . 21404877 .
5. ((Drug Enforcement Administration, Department of Justice)) . Schedules of Controlled Substances: Temporary Placement of ortho-Fluorofentanyl, Tetrahydrofuranyl Fentanyl, and Methoxyacetyl Fentanyl Into Schedule I. Temporary amendment; temporary scheduling order . Federal Register . 82 . 206 . 49504–49508 . October 2017 . 29091366 .