Tetrahydrocortisol Explained

Tetrahydrocortisol, or urocortisol, also known as 3α,11β,17α,21-tetrahydroxy-5β-pregnan-20-one, is a steroid and an inactive metabolite of cortisol.^[1]

Tetrahydrocortisol is a neurosteroid and has been found to act as a negative allosteric modulator of the GABA_A receptor, similarly to pregnenolone sulfate.^{[2] [3] [4]}

See also

• Tetrahydrocortisone
• Tetrahydrocorticosterone

Notes and References

1. Book: Thomas L. Lemke. David A. Williams. Foye's Principles of Medicinal Chemistry. 24 January 2012. Lippincott Williams & Wilkins. 978-1-60913-345-0. 915–.
2. Nikolaou N, Hodson L, Tomlinson JW . The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies . J Steroid Biochem Mol Biol . 207 . 105808 . March 2021 . 33418075 . 10.1016/j.jsbmb.2021.105808 . 230716310 .
3. Chen M, Penning TM . 5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1) . Steroids . 83 . 17–26 . May 2014 . 24513054 . 3971473 . 10.1016/j.steroids.2014.01.013 .
4. Penland SN, Morrow AL . 3alpha,5beta-Reduced cortisol exhibits antagonist properties on cerebral cortical GABA(A) receptors . Eur J Pharmacol . 506 . 2 . 129–32 . December 2004 . 15588732 . 10.1016/j.ejphar.2004.11.007 .