Testosterone 17b-dehydrogenase (NADP+) explained

Testosterone 17beta-dehydrogenase (NADP+)
Ec Number:1.1.1.64
Cas Number:9028-63-1

Testosterone 17beta-dehydrogenase (NADP+) (17-ketoreductase, NADP-dependent testosterone-17beta-oxidoreductase, testosterone 17beta-dehydrogenase (NADP)) is an enzyme with systematic name 17beta-hydroxysteroid:NADP+ 17-oxidoreductase.[1] [2] [3] This enzyme catalyses the following chemical reaction

testosterone + NADP+

\rightleftharpoons

androstenedione + NADPH + H+

Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.

Notes and References

  1. Endahl GL, Kochakian CD, Hamm D . Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver . The Journal of Biological Chemistry . 235 . 2792–6 . October 1960 . 13696735 .
  2. Sweat ML, Samuels LT, Lumry R . Preparation and characterization of the enzyme which converts testosterone to androstenedione . The Journal of Biological Chemistry . 185 . 1 . 75–84 . July 1950 . 15436478 .
  3. Villee CA, Spencer JM . Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver . The Journal of Biological Chemistry . 235 . 3615–9 . December 1960 . 13781425 .

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