Testifenon Explained

Testifenon, also known as testiphenon, testiphenone, chlorphenacyl dihydrotestosterone ester, or dihydrotestosterone 17β-(4-(bis(2-chloroethyl)amino)phenyl)acetate, is a synthetic anabolic–androgenic steroid (AAS) and a cytostatic antineoplastic agent (i.e., chemotherapeutic) that was never marketed.^{[1] [2] [3]} It is an androgen ester – specifically, a chlorphenacyl nitrogen mustard ester of dihydrotestosterone (DHT) – and acts as a prodrug of these two components in the body. The drug was developed in Russia as a tissue-selective cytostatic drug for the treatment of various cancers occurring in androgen receptor-expressing tissues that would have reduced side effects and toxicity relative to other chemotherapy drugs.

See also

• List of hormonal cytostatic antineoplastic agents
• List of androgen esters § Dihydrotestosterone esters

Notes and References

1. Lagova ND, Sof'ina ZP, Shkodinskaia EN, Kurdiumova KN, Valueva IM . [The antineoplastic activity of testiphenon] . ru . Voprosy Onkologii . 34 . 11 . 1363–1368 . 1988 . 3201773 .
2. Demidova NV, Serebryakova EA, Gasan-Guseinova ZG, Zimakova NI, Arzamastsev AP . Comparative pharmacokinetics of 3H-testiphenone and 3H-chlorophenacyl in peroral administration to mice. . Pharmaceutical Chemistry Journal . November 1995 . 29 . 11 . 737–739 . 10.1007/BF02331848 . 31434647 .
3. Oborotova NA, Smirnova ZS, Polozkova ZS, Baryshnikov AI . [Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics] . ru . Vestnik Rossiiskoi Akademii Meditsinskikh Nauk . 1 . 42–45 . 2002 . 11882971 .