Testicular receptor explained

Hgncid:	7971
Symbol:	NR2C1
Altsymbols:	TR2
Entrezgene:	7181
Omim:	601529
Refseq:	NM_003297
Uniprot:	P13056
Chromosome:	12
Arm:	q
Band:	22

Hgncid:	7972
Symbol:	NR2C2
Altsymbols:	TR4
Entrezgene:	7182
Omim:	601426
Refseq:	NM_003298
Uniprot:	P49116
Chromosome:	3
Arm:	p
Band:	25

The testicular receptor proteins are members of the nuclear receptor family of intracellular transcription factors.^[1] There are two forms of the receptor, TR2 and TR4, each encode by a separate gene (and respectively).^{[2] [3] [4]}

Notes and References

1. Lee YF, Lee HJ, Chang C . Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily . J. Steroid Biochem. Mol. Biol. . 81 . 4–5 . 291–308 . 2002 . 12361719 . 10.1016/S0960-0760(02)00118-8 . 11638283 .
2. Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y . Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains . Biochem. Biophys. Res. Commun. . 165 . 2 . 735–41 . 1989 . 2597158 . 10.1016/S0006-291X(89)80028-2 .
3. Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD . New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene . Genomics . 35 . 2 . 361–6 . 1996 . 8661150 . 10.1006/geno.1996.0368 .
4. Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP . Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily . Proc. Natl. Acad. Sci. U.S.A. . 91 . 13 . 6040–4 . 1994 . 8016112 . 10.1073/pnas.91.13.6040 . 44133 . 1994PNAS...91.6040C . free .