| Jurisdiction: | Diocese |
| San Juan de Calama | |
| Latin: | Sancti Ioannis Calamensis |
| Local: | Diócesis de San Juan Bautista de Calama |
| Rite: | Latin Rite |
| Established: | 21 July 1965 (years ago) |
| Cathedral: | Cathedral of St John the Baptist in Calama |
| Area Km2: | 43,000 |
| Population: | 191,000 |
| Population As Of: | 2014 |
| Catholics: | 150,300 |
| Catholics Percent: | 78.7 |
| Bishop: | Vacant |
| Metro Archbishop: | Ignacio Francisco Ducasse Medina |
| Website: | www.iglesiadecalama.cl |
The Diocese of San Juan de Calama (Latin: Sancti Ioannis Calamensis) is a diocese located in the city of Calama in the ecclesiastical province of Antofagasta in Chile.