Terpestacin Explained

Terpestacin is a fungal metabolite first isolated from Arthrinium.^[1]

In preliminary research, it has been studied for its potential anti-HIV^[1] and anti-cancer potential.^{[2] [3]}

A laboratory synthesis of terpestacin has been reported.^[4]

External links

• Grigoriev PA, Schlegel B, Schmidtke M, Gräfe U . Alteration of membrane polarization by (−)-terpestacin, a biologically active fungal metabolite . Die Pharmazie . 57 . 9 . 653–4. September 2002 . 12369460.

Notes and References

1. 10.1016/0040-4039(93)85110-I . Terpestacin, a novel syncytium formation inhibitor, isolated from Arthrinium species . 1993 . Iimura . Seiji . Oka . Masahisa . Narita . Yukio . Konishi . Masataka . Kakisawa . Hiroshi . Gao . Qi . Oki . Toshikazu . Tetrahedron Letters . 34 . 3 . 493–496 .
2. Jung HJ, Shim JS, Lee J, Song YM, Park KC, Choi SH, Kim ND, Yoon JH, Mungai PT, Schumacker PT, Kwon HJ . Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. J Biol Chem . 285 . 15 . 11584–95. April 2010 . 20145250 . 10.1074/jbc.M109.087809 . 2857036. free.
3. Park KC, Choi SH . Effects of endostatin and a new drug terpestacin against human neuroblastoma xenograft and cell lines . Pediatric Surgery International . 29 . 12 . 1327–40 . December 2013 . 24072200 . 10.1007/s00383-013-3398-1. 13088535 .
4. Chan. Johann. Jamison. Timothy F.. Synthesis of (−)-Terpestacin via Catalytic, Stereoselective Fragment Coupling: Siccanol Is Terpestacin, Not 11- -Terpestacin. Journal of the American Chemical Society. September 2003. 125. 38. 11514–11515. 10.1021/ja0373925. 13129351.