Tenascin-R Explained

Tenascin-R is a protein that in humans is encoded by the TNR gene.^{[1] [2] [3]}

Function

Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes 4 genes in mammals: TNC (or hexabrachion), TNX (TNXB), TNW (also known as TNN) and TNR.^{[4] [5]} The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM]^[3]

Further reading

• Erickson HP . Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions . Current Opinion in Cell Biology . 5 . 5 . 869–76 . October 1993 . 7694605 . 10.1016/0955-0674(93)90037-Q .
• Xiao ZC, Taylor J, Montag D, Rougon G, Schachner M . Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11 . The European Journal of Neuroscience . 8 . 4 . 766–82 . April 1996 . 9081628 . 10.1111/j.1460-9568.1996.tb01262.x . 30389358 .
• Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y . The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety . Proceedings of the National Academy of Sciences of the United States of America . 94 . 19 . 10116–21 . September 1997 . 9294172 . 23322 . 10.1073/pnas.94.19.10116 . 1997PNAS...9410116A . free .
• Xiao ZC, Hillenbrand R, Schachner M, Thermes S, Rougon G, Gomez S . Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R . Journal of Neuroscience Research . 49 . 6 . 698–709 . September 1997 . 9335257 . 10.1002/(SICI)1097-4547(19970915)49:6<698::AID-JNR4>3.0.CO;2-2 . 10209383 .
• Arrigo G, Gherzi R, Bonaglia MC, Leprini A, Zuffardi O, Zardi L . Assignment of the tenascin-R gene (Tnr) to mouse chromosome 4 band E2 by fluorescence in situ hybridization; refinement of the human TNR location to chromosome 1q24 . Cytogenetics and Cell Genetics . 78 . 2 . 145–6 . 1997 . 9371410 . 10.1159/000134650 .
• Volkmer H, Zacharias U, Nörenberg U, Rathjen FG . Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells . The Journal of Cell Biology . 142 . 4 . 1083–93 . August 1998 . 9722619 . 2132869 . 10.1083/jcb.142.4.1083 .
• Zamze S, Harvey DJ, Pesheva P, Mattu TS, Schachner M, Dwek RA, Wing DR . Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans . Glycobiology . 9 . 8 . 823–31 . August 1999 . 10406848 . 10.1093/glycob/9.8.823 . free . 20.500.11850/422721 . free .
• Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A . The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding . The Journal of Biological Chemistry . 276 . 2 . 1253–61 . January 2001 . 11038354 . 10.1074/jbc.M006783200 . free .
• Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG . Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver . Proceedings of the National Academy of Sciences of the United States of America . 98 . 26 . 15089–94 . December 2001 . 11752456 . 64988 . 10.1073/pnas.241522398 . 2001PNAS...9815089X . free .
• Woodworth A, Pesheva P, Fiete D, Baenziger JU . Neuronal-specific synthesis and glycosylation of tenascin-R . The Journal of Biological Chemistry . 279 . 11 . 10413–21 . March 2004 . 14681222 . 10.1074/jbc.M312466200 . free .
• Bukalo O, Schachner M, Dityatev A . Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R . The Journal of Neuroscience . 27 . 22 . 6019–28 . May 2007 . 17537973 . 10.1523/JNEUROSCI.1022-07.2007 . 6672247 . free .

Notes and References

1. Carnemolla B, Leprini A, Borsi L, Querzé G, Urbini S, Zardi L . Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24 . The Journal of Biological Chemistry . 271 . 14 . 8157–60 . April 1996 . 8626505 . 10.1074/jbc.271.14.8157 . free .
2. Leprini A, Gherzi R, Siri A, Querzé G, Viti F, Zardi L . The human tenascin-R gene . The Journal of Biological Chemistry . 271 . 49 . 31251–4 . December 1996 . 8940128 . 10.1074/jbc.271.49.31251 . free .
3. Web site: Entrez Gene: TNR tenascin R (restrictin, janusin).
4. Erickson HP . Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions . Current Opinion in Cell Biology . 5 . 5 . 869–76 . October 1993 . 7694605 . 10.1016/0955-0674(93)90037-Q .
5. Hsia . Henry C. . Schwarzbauer . Jean E. . July 2005 . Meet the Tenascins: Multifunctional and Mysterious . Journal of Biological Chemistry . en . 280 . 29 . 26641–26644 . 10.1074/jbc.R500005200. 15932878 . free .