Telangiectasia macularis eruptiva perstans explained

Telangiectasia macularis eruptiva perstans
Synonyms:TMEP

Telangiectasia macularis eruptiva perstans (TMEP) is persistent, pigmented, asymptomatic eruption of macules usually less than 0.5 cm in diameter with a slightly reddish-brown tinge.[1] [2]

Signs and symptoms

Small, irregular reddish-brown telangiectatic macules covering a tan to brown backdrop are the usual appearance of TMEP lesions.[3] The diameter of a single lesion is often between 2 and 4 mm.[4] During a diascopy, the telangiectatic lesions typically blanch. Lesions are usually non-pruritic and symmetrically distributed over the trunk and proximal extremities. Usually, the face, palms, and soles remain unharmed.[3] Darier's sign, a classic urticaria pigmentosa/maculopapular cutaneous mastocytosis finding, is usually negligible or absent in individuals with TMEP because the quantity of mast cells involved is comparatively lower.[4] [5]

Causes

There have been reports of family clustering within families in certain TMEP cases.[6] [7] Rare cases involving patients receiving radiation therapy, those suffering from malignant melanoma,[8] breast or kidney cancer,[9] or those with Sjogren's syndrome have also been reported.[10] Additional cases have been reported in individuals with leukemia[11] or myelofibrosis,[12] [13] multiple myeloma,[14] and myeloproliferative diseases (including Polycythemia Rubra Vera).[15] Rare instances of urticaria pigmentosa and TMEP coexisting have also been reported.[16] [17]

Diagnosis

Spindle-shaped mast cells found in skin biopsies validate the diagnosis of TMEP.[18] Histologically, TMEP is distinguished by a modest mononuclear infiltrate surrounding the superficial venous plexus capillaries that contains a considerable number of mast cells.[19] Special stains, such Giemsa or toluidine blue, are highly helpful in the diagnostic evaluation because they aid to highlight the presence of mast cells by exposing their metachromatic cytoplasmic granules.[20] [21] TMEP lesions' dermoscopy reveals linear dots organized in a reticular pattern.[22]

Treatment

The presence of systemic involvement or clinical symptoms determines how individuals with TMEP are treated. There is no gold standard medication for the treatment of TMEP, thus it is critical to identify and avoid conditions that trigger mast cell destruction, such as sunshine, severe temperatures, alcohol, and narcotics. H1 antagonists are used to treat urticaria and pruritus. Psoralen combined with UV radiation by preventing mast cells from releasing histamine, improves symptoms and causes skin lesions to disappear.[19]

See also

Further reading

External links

Notes and References

  1. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. .
  2. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 1845, 1848 . 978-1-4160-2999-1 .
  3. Watkins . Casey E. . Bokor . Winston B. . Leicht . Stuart . Youngberg . George . Krishnaswamy . Guha . Telangiectasia Macularis Eruptiva Perstans: more than skin deep . Dermatology Reports . PAGEPress Publications . 3 . 1 . 2011-07-29 . 2036-7406 . 10.4081/dr.2011.e12 . e12. 25386256 .
  4. Wolff . Klaus . Komar . Michael . Petzelbauer . Peter . Clinical and histopathological aspects of cutaneous mastocytosis . Leukemia Research . Elsevier BV . 25 . 7 . 2001 . 0145-2126 . 10.1016/s0145-2126(01)00044-3 . 519–528. 11377676 .
  5. Vidal . C. . del Rio . E. . Suárez-Peñaranda . J. . Armisén . M. . Telangiectasia macularis eruptiva perstans presented as a pseudoallergic food reaction . Journal of Investigational Allergology & Clinical Immunology . 10 . 4 . 2000 . 1018-9068 . 11039843 . 248–250.
  6. NERI . I. . GUARESCHI . E. . GUERRINI . V. . PATRIZI . A. . Familial Telangiectasia Macularis Eruptiva Perstans . Pediatric Dermatology . Wiley . 22 . 5 . 2005 . 0736-8046 . 10.1111/j.1525-1470.2005.00123.x . 488–489. 16191009 .
  7. Chang . Anwell . Tung . Rebecca C. . Schlesinger . Todd . Bergfeld . Wilma F. . Dijkstra . Jacob . Kahn . Teri A. . Familial Cutaneous Mastocytosis . Pediatric Dermatology . Wiley . 18 . 4 . 2001 . 0736-8046 . 10.1046/j.1525-1470.2001.01939.x . 271–276. 11576397 .
  8. Kowalzic . Lutz . Eickenscheidt . Lena . Seidel . Christoph . Kribus . Sabine . Ziegler . Heidrun . Komar . Michael . Telangiectasia macularis eruptiva perstans, a form of cutaneous mastocytosis, associated with malignant melanoma . JDDG: Journal der Deutschen Dermatologischen Gesellschaft . Wiley . 7 . 4 . 2009-03-30 . 1610-0379 . 10.1111/j.1610-0387.2008.06941.x . 360–362. 19054427 .
  9. Carlos Pascual . José . Bañuls . José . Albares . Ma Pilar . Vergara . Gloria . Belinchón . Isabel . Francisco Silvestre . Juan . Betlloch . Isabel . Presentation of Telangiectasia Macularis Eruptiva Perstans as a Long-Standing Solitary Plaque Associated with Renal Carcinoma . Journal of Cutaneous Medicine and Surgery: Incorporating Medical and Surgical Dermatology . SAGE Publications . 7 . 5 . 2003-10-01 . 1203-4754 . 10.1007/s10227-002-0144-z . 399–402. 14973646 .
  10. Kalay Erbay . Shebnem . Stewart . Carol . Hassanein . Ashraf . Fletcher . Andrew . Bhattacharyya . Indraneel . Cohen . Donald . Wesson . Stanton K. . Weinstein . Jason . Lyons . Robert . Reeves . Westley H. . Cutaneous mastocytosis in a patient with primary Sjögren's syndrome . The Journal of Rheumatology . 33 . 8 . 2006 . 0315-162X . 16881127 . 1697–1700.
  11. Mahadeo . Kris M. . Wolgast . Lucia . McMahon . Christine . Cole . Peter D. . Systemic Mastocytosis in a Child With t(8;21) Acute Myeloid Leukemia . Pediatric Blood & Cancer . Wiley . 57 . 4 . 2011-02-04 . 1545-5009 . 10.1002/pbc.23026 . 684–687. 21671435 .
  12. Turchin . Irina . Barankin . Benjamin . Schloss . Eric . Unusual cutaneous findings of urticaria pigmentosa and telangiectasia macularis eruptiva perstans associated with marked myelofibrosis . International Journal of Dermatology . Wiley . 45 . 10 . 2006 . 0011-9059 . 10.1111/j.1365-4632.2006.02648.x . 1215–1217. 17040445 .
  13. Martin . Lucy K. . Romanelli . Paolo . Ahn . Yeon Soong . Kirsner . Robert S. . Telangiectasia macularis eruptiva perstans with an associated myeloproliferative disorder . International Journal of Dermatology . Wiley . 43 . 12 . 2004-08-09 . 0011-9059 . 10.1111/j.1365-4632.2004.02249.x . 922–924. 15569020 .
  14. Bachmeyer . Claude . Guillemette . Jacqueline . Blum . Laurent . Turc . Yves . Dhôte . Robin . Fermand . Jean-Paul . Aractingi . Selim . Telangiectasia macularis eruptiva perstans and multiple myeloma . Journal of the American Academy of Dermatology . Elsevier BV . 43 . 5 . 2000 . 0190-9622 . 10.1067/mjd.2000.109254 . 972–974. 11044837 .
  15. Suzuki . Kenji . Konishi . Noriko . Tokura . Yoshiki . Takigawa . Masahiro . Telangiectasia macularis eruptiva perstans in polycythemia rubra vera . European Journal of Dermatology: EJD . 12 . 2 . 2002 . 1167-1122 . 11872425 . 201–203.
  16. Parks . A. . Reddish-brown macules with telangiectasia and pruritus. Urticaria pigmentosa-telangiectasia macularis eruptiva perstans (TMEP) variant, with systemic mastocytosis . Archives of Dermatology . American Medical Association (AMA) . 124 . 3 . 1988-03-01 . 0003-987X . 10.1001/archderm.124.3.429b . 429b–430. 3345092 .
  17. Weber . F. Parkes . Telangiectasia Macularis Eruptiva Perstans—probably a telangiectatic variety of urticaria pigmentosa in an adult . Proceedings of the Royal Society of Medicine . Royal Society of Medicine Press . 24 . 2 . 2024-03-14 . 96–97 . 10.1177/003591573002400204 . 19987891 . 2182058 .
  18. Cengizlier . R. . Hücümenoğlu . S. . Özen . A. . Tülin Şayli . R. . Treatment of telangiectasia macularis eruptiva perstans with montelukast . Allergologia et Immunopathologia . Codon Publications . 37 . 6 . 2009 . 0301-0546 . 10.1016/j.aller.2009.03.010 . 334–336. 19913347 .
  19. Costa . Dailana Louvain Marinho . Moura . Heloisa Helena . Rodrigues . Rosangela . Pineiro-Maceira . Juan . Ramos-e-Silva . Marcia . Telangiectasia Macularis Eruptiva Perstans: A Rare Form of Adult Mastocytosis . The Journal of Clinical and Aesthetic Dermatology . Matrix Medical Communications . 4 . 10 . 2024-03-14 . 52–54 . 22010057 . 3196299 .
  20. Gibbs . Neil F. . Friedlander . Sheila Fallon . Harpster . Elaine F. . Telangiectasia Macularis Eruptiva Perstans . Pediatric Dermatology . Wiley . 17 . 3 . 2000 . 0736-8046 . 10.1046/j.1525-1470.2000.01750.x . 194–197. 10886750 .
  21. Sotiriou . Eleni . Apalla . Zoi . Ioannides . Demetris . Telangiectasia macularis eruptive perstans successfully treated with PUVA therapy . Photodermatology, Photoimmunology & Photomedicine . Wiley . 26 . 1 . 2010 . 0905-4383 . 10.1111/j.1600-0781.2009.00480.x . 46–47. 20070840 .
  22. Akay . Bengü Nisa . Kittler . Harald . Sanlı . Hatice . Harmankaya . Kaan . Anadolu . Rana . Dermatoscopic Findings of Cutaneous Mastocytosis . Dermatology . S. Karger AG . 218 . 3 . 2008-12-06 . 1018-8665 . 10.1159/000182260 . 226–230. 19060465 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Telangiectasia macularis eruptiva perstans".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.