Tegoprubart Explained

Drug Name:	Tegoprubart
Synonyms:	AT-1501
Type:	mab
Legal Status:	Investigational
Cas Number:	2628092-47-5
Unii:	EK87C62XNH

Tegoprubart (AT-1501) is an experimental humanized monoclonal antibody that inhibits CD40L. It is developed for ALS^[1] and transplant rejection.^{[2] [3] [4] [5]}

Notes and References

1. Meglio, Marco. "Tegoprubart Demonstrates Safety, Target Engagement of ALS Markers in Phase 2 Study." Neurology Times, 3 Nov. 2022, p. NA. Gale Academic OneFile, link.gale.com/apps/doc/A762611032/AONE?u=anon~b1a7e306&sid=googleScholar&xid=733a3e0e. Accessed 4 Dec. 2023.
2. Gendron . Tania F. . Petrucelli . Leonard . Immunological drivers of amyotrophic lateral sclerosis . Science Translational Medicine . 8 November 2023 . 15 . 721 . eadj9332 . 10.1126/scitranslmed.adj9332. 37939160 . 265051444 .
3. Singh . Avneesh K. . Goerlich . Corbin E. . Zhang . Tianshu . Lewis . Billeta G.T. . Hershfeld . Alena . Mohiuddin . Muhammad M. . CD40-CD40L Blockade: Update on Novel Investigational Therapeutics for Transplantation . Transplantation . July 2023 . 107 . 7 . 1472–1481 . 10.1097/TP.0000000000004469. 36584382 . 10287837 .
4. Anwar . Imran J. . Berman . Dora M. . DeLaura . Isabel . Gao . Qimeng . Willman . Melissa A. . Miller . Allison . Gill . Alan . Gill . Cindy . Perrin . Steve . Ricordi . Camillo . Ruiz . Philip . Song . Mingqing . Ladowski . Joseph M. . Kirk . Allan D. . Kenyon . Norma S. . The anti-CD40L monoclonal antibody AT-1501 promotes islet and kidney allograft survival and function in nonhuman primates . Science Translational Medicine . 30 August 2023 . 15 . 711 . eadf6376 . 10.1126/scitranslmed.adf6376. 37647390 . 261340684 . 10990482 .
5. Gill . John . Coates . Patrick . Tchervenkov . Jean . Bornstein . Jeffrey . Harden . Paul . Kadatz . Matthew . Witkowski . Piotr . 318.5: Emerging data from a study of tegoprubart for the prevention of rejection in kidney transplant recipients: Implications for a similar study in islet cell transplantation . Transplantation . October 2023 . 107 . 10S2 . 124 . 10.1097/01.tp.0000994460.57811.03. free .