Teg49 small RNA explained

Teg49 sRNA
Rfam:RF02696
Tax Domain:Bacteria

Teg49 is a non-coding RNA present in the extended promoter region of the staphylococcal accessory regulator sarA. It was identified by RNA-seq and confirmed by Northern blot. It is modulated by sigB (sarA regulator[1]) and cshA (an ATP-dependant DEAD box RNA helicase[2]) and it most likely contributes to virulence of S. aureus by modulating SarA expression.[3]

Notes and References

  1. Cheung AL, Chien YT, Bayer AS . Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus . Infection and Immunity . 67 . 3 . 1331–1337 . March 1999 . 10.1128/IAI.67.3.1331-1337.1999 . 10024579 . 96465 .
  2. Oun S, Redder P, Didier JP, François P, Corvaglia AR, Buttazzoni E, Giraud C, Girard M, Schrenzel J, Linder P . The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus . RNA Biology . 10 . 1 . 157–165 . January 2013 . 23229022 . 3590232 . 10.4161/rna.22899 .
  3. Kim S, Reyes D, Beaume M, Francois P, Cheung A . Contribution of teg49 small RNA in the 5′ upstream transcriptional region of sarA to virulence in Staphylococcus aureus . Infection and Immunity . 82 . 10 . 4369–4379 . October 2014 . 25092913 . 4187880 . 10.1128/IAI.02002-14 .

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