Technetium (99mTc) tilmanocept explained

Drug Name:

Technetium (^99mTc) tilmanocept

Width:

400

Tradename:

Lymphoseek

Dailymedid:

Tilmanocept

Pregnancy Au:

C

Routes Of Administration:

Intradermal, subcutaneous, intratumor

Atc Prefix:

V09

Atc Suffix:

IA09

Legal Au:

S4

Legal Au Comment:

^{[1] [2]}

Legal Uk:

POM

Legal Uk Comment:

^[3]

Legal Us:

Rx-only

Legal Us Comment:

^[4]

Legal Eu:

Rx-only

Legal Eu Comment:

^[5]

Elimination Half-Life:

1.75 to 3.05 hours at injection site

Cas Number:

1262984-82-6

Unii:

8IHI69PQTC

Kegg:

D11543

Synonyms:

technetium Tc 99m tilmanocept

Iupac Name:

Dextran 3-[(2-aminoethyl)thio]propyl 17-carboxy-10,13,16-tris(carboxymethyl)-8-oxo-4-thia-7,10,13,16-tetraazaheptadec-1-yl 3-2-1-imino-2-(D-mannopyranosylthio)ethylamino]ethylthio]propyl ether technetium-99m complexes| chemical_formula = (C₆H₁₀O₅)_n(C₁₉H₂₈N₄O₉S^99mTc)_3–8(C₁₃H₂₄N₂O₅S₂)_12–20(C₅H₁₁NS)_0–17| molecular_weight = 15,281–23,454 g/mol}}

Technetium (^99mTc) tilmanocept, sold under the brand name Lymphoseek, is a radiopharmaceutical diagnostic imaging agent used to locate lymph nodes which may be draining from tumors, and assist doctors in locating lymph nodes for removal during surgery.^[6]

The most common side effects include pain or irritation at the injection site.

It was approved for medical use in the United States in March 2013,^[7] and in the European Union in November 2014.

Medical uses

In the US, technetium (^99mTc) tilmanocept is indicated with or without scintigraphic imaging for lymphatic mapping using a handheld gamma counter to locate lymph nodes draining a primary tumor site in people with solid tumors for which this procedure is a component of intraoperative management; and guiding sentinel lymph node biopsy using a handheld gamma counter in people with clinically node negative squamous cell carcinoma of the oral cavity, breast cancer or melanoma.

In the EU, technetium (^99mTc) tilmanocept is indicated for imaging and intraoperative detection of sentinel lymph nodes draining a primary tumor in adults with breast cancer, melanoma, or localized squamous cell carcinoma of the oral cavity. External imaging and intraoperative evaluation may be performed using a gamma detection device.

History

The safety and effectiveness of technetium (^99mTc) tilmanocept were established in two clinical trials of 332 participants with melanoma or breast cancer. All participants were injected with technetium (^99mTc) tilmanocept and blue dye, another drug used to help locate lymph nodes.

References

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Notes and References

1. Web site: Lymphoseek kit for the preparation of technetium [99m Tc] tilmanocept injection vial ]. Therapeutic Goods Administration (TGA) . 28 October 2020.
2. Web site: Summary for ARTG Entry: 296337 Lymphoseek kit for the preparation of technetium [99m Tc] tilmanocept injection vial ]. Therapeutic Goods Administration (TGA) . PDF . 28 October 2020.
3. Web site: Lymphoseek 50 micrograms kit for radiopharmaceutical preparation - Summary of Product Characteristics (SmPC) . (emc) . 18 May 2020 . 28 October 2020.
4. Web site: Kit for the preparation of Lymphoseek (technetium tc 99m tilmanocept)- tilmanocept kit . DailyMed . 8 July 2019 . 28 October 2020.
5. Web site: Lymphoseek EPAR . European Medicines Agency (EMA) . 17 September 2018 . 28 October 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
6. Marcinow AM, Hall N, Byrum E, Teknos TN, Old MO, Agrawal A . Use of a novel receptor-targeted (CD206) radiotracer, 99mTc-tilmanocept, and SPECT/CT for sentinel lymph node detection in oral cavity squamous cell carcinoma: initial institutional report in an ongoing phase 3 study . JAMA Otolaryngology–Head & Neck Surgery . 139 . 9 . 895–902 . September 2013 . 24051744 . 4301415 . 10.1001/jamaoto.2013.4239 .
7. FDA approves Lymphoseek to help locate lymph nodes in patients with certain cancers . U.S. Food and Drug Administration (FDA) . 13 March 2013 . https://web.archive.org/web/20140330143659/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm343525.htm . 30 March 2014 . dead .