Tebipenem Explained

Tebipenem (brand name Orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics. It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics.[1] [2] Tebipenem is formulated as the ester tebipenem pivoxil due to the better absorption and improved bioavailability of this form.[3] It has performed well in clinical trials for ear infection and looks likely to be further developed in future.[4] It is only marketed in Japan.[5] Tebipenem is the first carbapenem whose prodrug form, the pivalyl ester, is orally available.[6]

Notes and References

  1. El-Gamal MI, Oh CH . Current status of carbapenem antibiotics . Current Topics in Medicinal Chemistry . 10 . 18 . 1882–97 . 2010 . 20615191 . 10.2174/156802610793176639 .
  2. Fujimoto K, Takemoto K, Hatano K, Nakai T, Terashita S, Matsumoto M, Eriguchi Y, Eguchi K, Shimizudani T, Sato K, Kanazawa K, Sunagawa M, Ueda Y . 6 . Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals . Antimicrobial Agents and Chemotherapy . 57 . 2 . 697–707 . February 2013 . 23147735 . 3553697 . 10.1128/AAC.01051-12 .
  3. Kato K, Shirasaka Y, Kuraoka E, Kikuchi A, Iguchi M, Suzuki H, Shibasaki S, Kurosawa T, Tamai I . 6 . Intestinal absorption mechanism of tebipenem pivoxil, a novel oral carbapenem: involvement of human OATP family in apical membrane transport . Molecular Pharmaceutics . 7 . 5 . 1747–56 . October 2010 . 20735088 . 10.1021/mp100130b .
  4. Sugita R . 1228827 . Good transfer of tebipenem into middle ear effusion conduces to the favorable clinical outcomes of tebipenem pivoxil in pediatric patients with acute otitis media . Journal of Infection and Chemotherapy . 19 . 3 . 465–71 . June 2013 . 23393013 . 10.1007/s10156-012-0513-5 .
  5. Web site: Tebipenem Pivoxil. 7 August 2014. 6 April 2015. London, UK . Pharmaceutical Press . Martindale: The Complete Drug Reference. Rossi S .
  6. Hazra S, Xu H, Blanchard JS . Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis . Biochemistry . 53 . 22 . 3671–8 . June 2014 . 24846409 . 4053071 . 10.1021/bi500339j .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tebipenem".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.