Tazomeline Explained

Tazomeline (LY-287,041) is a drug which acts as a non-selective muscarinic acetylcholine receptor agonist.[1] [2] It was in clinical trials for the treatment of cognitive dysfunction such as that seen in Alzheimer's disease and schizophrenia, but development was apparently scrapped for unknown reasons.[1] [2] [3] Another of the patented uses is for the treatment of "severe painful conditions".

See also

Notes and References

  1. Langmead CJ, Watson J, Reavill C . Muscarinic acetylcholine receptors as CNS drug targets . Pharmacology & Therapeutics . 117 . 2 . 232–43 . February 2008 . 18082893 . 10.1016/j.pharmthera.2007.09.009 .
  2. Amos D Korczyn . Muscarinic M1 Agonists in the Treatment of Alzheimer's Disease . Expert Opinion on Investigational Drugs . 9 . 10 . 2259–2267(9) . October 2000 . 10.1517/13543784.9.10.2259 . 11060805 . 32214700 .
  3. Mashkovskii MD, Glushkov RG . Drugs for the Treatment of Alzheimer's Disease . Pharmaceutical Chemistry Journal . 35 . 4 . 179–182 . April 2001 . 10.1023/A:1010474325601 . 39866378 .

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