Taxuspines Explained

Taxuspines is a class of taxanes, which are encountered in several species of the genus Taxus.Typically, they are several types of them, named as taxuspines A ~ H and J. These new taxoids recently have been discovered in the Japanese yew, Taxus cuspidata.^[1] Taxuspines E ~ H and J (1 ~ 5), have been isolated from stems and leaves of the Japanese yew Taxus cuspidata Sieb. et Zucc.

Taxuspine E (1) exhibited potent cytotoxicity against KB cells.^[2]

See also

• Docetaxel
• Taxane
• Taxuyunnanine

Notes and References

1. Kobayashi . Jun'ichi . Inubushi . Akiko . Hosoyama . Hirokazu . Yoshida . Naotoshi . Sasaki . Takuma . Shigemori . Hideyuki . Taxuspines E ~ H and J, new taxoids from the Japanese yew Taxus cuspidata . Tetrahedron . Elsevier BV . 51 . 21 . 1995 . 0040-4020 . 10.1016/0040-4020(95)00255-7 . 5971–5978.
2. Kobayashi . Juníchi . Ogiwara . Aya . Hosoyama . Hirokazu . Shigemori . Hideyuki . Yoshida . Naotoshi . Sasaki . Takuma . Li . Yin . Iwasaki . Shigeo . Naito . Mikihiko . Tsuruo . Takashi . Taxuspines A ~ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells . Tetrahedron . Elsevier BV . 50 . 25 . 1994 . 0040-4020 . 10.1016/s0040-4020(01)90470-3 . 7401–7416.