Taxoid 14beta-hydroxylase explained

Taxoid 14beta-hydroxylase
Ec Number:	1.14.13.146

Taxoid 14beta-hydroxylase is an enzyme with systematic name 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O₂ + NADPH + H⁺

\rightleftharpoons 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP⁺ + H₂O

Taxoid 14beta-hydroxylase requires cytochrome P450.

Notes and References

1. Jennewein S, Rithner CD, Williams RM, Croteau R . Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase . Archives of Biochemistry and Biophysics . 413 . 2 . 262–70 . May 2003 . 12729625 . 10.1016/s0003-9861(03)00090-0 .