| Box Width: | auto |
| Taranto–Brindisi railway | |
| Type: | Heavy rail |
| Status: | Operational |
| Locale: | Apulia, Italy |
| Start: | Taranto railway station |
| End: | Brindisi railway station |
| Stations: | 12 |
| Open: | 1886 |
| Operator: | Rete Ferroviaria Italiana |
| Linelength: | 70km (40miles) |
| Tracks: | Single track |
| Linenumber: | 135 |
| Electrification: | Electrified at 3000 V DC |
The Taranto–Bridisi railway is an Italian 70-kilometre long railway line, connecting Taranto with Brindisi.
The line was opened in three stages in 1886. On 6 January 1886 the section from Taranto to Latiano opened, then with effect from 25 August 1886 the line was further extended from Latiano to Mesagne, and finally on 30 December 1886 the final length from Mesagne to Brindisi came into use.
The line is used by the following service(s):