Tanmay A. M. Bharat Explained

Tanmay A. M. Bharat is a programme leader in the Structural Studies Division of the MRC Laboratory of Molecular Biology.[1] He and his group use electron tomography, together with several structural and cell biology methods to study the cell surfaces of bacteria and archaea. His work has increased the understanding of how surface molecules help in the formation of multicellular communities of prokaryotes, examples of which include biofilms and microbiomes.[2] He has been awarded several prizes and fellowships for his work.[3] [4]

Education

Bharat graduated with a BA in Biological Sciences from the University of Oxford, UK. His studies were supported by a Rhodes Scholarship. He then undertook research at the European Molecular Biology Laboratory in Heidelberg, Germany for his PhD working with John A. G. Briggs.[5] He studied the structure and assembly of pathogenic viruses using cryogenic electron microscopy and tomography. His work on several viral capsid proteins improved understanding of how viruses are assembled within infected cells.[6] [7] [8] [9]

Research

He subsequently joined the MRC Laboratory of Molecular Biology (LMB) in Cambridge to pursue post-doctoral research with Jan Löwe using cryo-EM to study proteins within bacterial cells.[10] [11] [12] After his post-doctoral appointment concluded, he was recruited to the Sir William Dunn School of Pathology, University of Oxford as a Wellcome Trust and Royal Society Sir Henry Dale Fellow.[13] After obtaining tenure at Oxford, he moved back to the LMB as a programme leader in 2022.[14] His research investigates how bacteria and archaea use their surface molecules to form multicellular communities. For instance, during human infections bacteria form biofilms that help them evade antibiotics. The group also use electron tomography.[6]

Scientific publications

Bharat is the author or co-author of over 46 scientific publications. These include:

Awards

Bharat has been awarded many prizes and fellowships. These include a 2018 Vallee Research Scholarship, the 2019 EMBL John Kendrew Award[15] the 2020 Philip Leverhulme Prize for Biological Sciences,[16] the 2021 Eppendorf Award for Young European Investigators,[17] and the 2021 Lister Prize,[18] the 2022 Colworth Medal from the Biochemical Society and the 2023 Fleming Prize from the Microbiology Society.[4]

Notes and References

  1. Web site: Biology . ©2023 MRC Laboratory of Molecular . Avenue . Francis Crick . Campus . Cambridge Biomedical . CB2 0QH . Cambridge . Uk. 01223 267000 . Tanmay Bharat . 2023-12-12 . MRC Laboratory of Molecular Biology . en-GB.
  2. Web site: Tanmay Bharat, PhD The Vallee Foundation . 2023-12-12 . thevalleefoundation.org.
  3. Web site: Tanmay Bharat Prokaryotic cell surfaces . MRC Laboratory of Molecular Biology . UKRI . 26 October 2023.
  4. Web site: FLEMING PRIZE WINNERS . Microbiology Society . 28 April 2020.
  5. Web site: Vallee Scholar Awards: Tanmay Bharat, PhD . The Vallee Foundation . 26 October 2023.
  6. Web site: The Colworth Medal . Biochemical Society . 8 September 2022.
  7. Bharat . Tanmay A. M. . Riches . James D. . Kolesnikova . Larissa . Welsch . Sonja . Krähling . Verena . Davey . Norman . Parsy . Marie-Laure . Becker . Stephan . Briggs . John A. G. . 2011-11-15 . Cryo-electron tomography of Marburg virus particles and their morphogenesis within infected cells . PLOS Biology . 9 . 11 . e1001196 . 10.1371/journal.pbio.1001196 . 1545-7885 . 3217011 . 22110401 . free .
  8. Bharat . Tanmay A. M. . Noda . Takeshi . Riches . James D. . Kraehling . Verena . Kolesnikova . Larissa . Becker . Stephan . Kawaoka . Yoshihiro . Briggs . John A. G. . 2012-03-13 . Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography . Proceedings of the National Academy of Sciences of the United States of America . 109 . 11 . 4275–4280 . 10.1073/pnas.1120453109 . 1091-6490 . 3306676 . 22371572 . 2012PNAS..109.4275B . free .
  9. Bharat . Tanmay A. M. . Davey . Norman E. . Ulbrich . Pavel . Riches . James D. . de Marco . Alex . Rumlova . Michaela . Sachse . Carsten . Ruml . Tomas . Briggs . John A. G. . 2012-07-19 . Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy . Nature . 487 . 7407 . 385–389 . 10.1038/nature11169 . 1476-4687 . 22722831. 2012Natur.487..385B . 4423300 .
  10. Web site: Kostic . Milka . MasterClass—Optimizing RELION for cryo-ET by Tanmay Bharat and Sjors Scheres . 2023-12-07 . crosstalk.cell.com . en-us.
  11. Bharat . Tanmay A. M. . Murshudov . Garib N. . Sachse . Carsten . Löwe . Jan . 2015-07-02 . Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles . Nature . 523 . 7558 . 106–110 . 10.1038/nature14356 . 1476-4687 . 4493928 . 25915019. 2015Natur.523..106B .
  12. van den Ent . Fusinita . Izoré . Thierry . Bharat . Tanmay Am . Johnson . Christopher M. . Löwe . Jan . 2014-05-02 . Bacterial actin MreB forms antiparallel double filaments . eLife . 3 . e02634 . 10.7554/eLife.02634 . 2050-084X . 4051119 . 24843005 . free .
  13. Web site: Structural cell biology of bacterial biofilm formation . 2023-12-07 . Wellcome . en.
  14. Web site: Tanmay Bharat CV . 2023-12-07 . www2.mrc-lmb.cam.ac.uk.
  15. Web site: The John Kendrew Award – Alumni relations . 2023-12-21 . en-GB.
  16. Web site: Philip Leverhulme Prizes 2020 The Leverhulme Trust . 2023-12-21 . www.leverhulme.ac.uk.
  17. Web site: 2021 Award Winner - Eppendorf Corporate . 2023-12-21 . corporate.eppendorf.com . en-EN.
  18. Web site: Tanmay Bharat Awarded Lister Institute Research Prize . Sir William Dunn School of Pathology . 26 October 2023.

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