Tandamine Explained

Tandamine is a selective norepinephrine reuptake inhibitor with a tricyclic structure.^{[1] [2] [3]} It was developed in the 1970s as an antidepressant but was never commercialized. Tandamine is analogous to pirandamine, which, instead, acts as a selective serotonin reuptake inhibitor (SSRI).^{[4] [5]}

The exact identical same structure, although this time changing the thioether to a methylene group revealed a strongest compound of the series called AY 24614.^[6]

See also

• Pirandamine

Notes and References

1. Lippmann W, Pugsley TA . The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities . Biochemical Pharmacology . 25 . 10 . 1179–1186 . May 1976 . 1084746 . 10.1016/0006-2952(76)90366-X .
2. Ehsanullah RS, Ghose K, Kirby MJ, Turner P, Witts D . Clinical pharmacological studies of tandamine, a potential antidepressive drug . Psychopharmacology . 52 . 1 . 73–77 . March 1977 . 403562 . 10.1007/BF00426603 . 23960347 .
3. Pugsley TA, Lippmann W . Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities . Naunyn-Schmiedeberg's Archives of Pharmacology . 308 . 3 . 239–247 . September 1979 . 503251 . 10.1007/BF00501388 . 23533861 .
4. Pugsley T, Lippmann W . Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities . Psychopharmacology . 47 . 1 . 33–41 . May 1976 . 1085452 . 10.1007/BF00428698 . 8354739 .
5. Lippmann W, Seethaler K . Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat . Life Sciences . 20 . 8 . 1393–1400 . April 1977 . 853871 . 10.1016/0024-3205(77)90367-8 .
6. Asselin AA, Humber LG, Komlossy J . Cycloalkanoindoles. 2. 1-Alkyl-1,2,3,4-tetrahydrocarbazole-1-ethanamines and related compounds. Potential antidepressants . Journal of Medicinal Chemistry . 19 . 6 . 792–797 . June 1976 . 950648 . 10.1021/jm00228a011 .