| Official Name: | Talcottville, New York |
| Other Name: | Leyden |
| Settlement Type: | Hamlet |
| Pushpin Map: | New York#USA |
| Pushpin Label: | Talcottville |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | New York |
| Subdivision Type2: | County |
| Subdivision Name2: | Lewis |
| Subdivision Type3: | Town |
| Subdivision Name3: | Leyden |
| Unit Pref: | Imperial |
| Population As Of: | 2010 |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 1135 |
| Coordinates: | 43.5333°N -75.3653°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 13309 (Boonville) |
| Area Code: | 315 |
| Blank Name: | FIPS code |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 967005 |
Talcottville is a small community in southern Lewis County, New York, United States. It is the seat for the town of Leyden.
Talcottville was the first settlement in Lewis County. William Topping and his family settled in 1793 on what is now the northwest corner of State Route 12D and Domser Road.
Active businesses in the hamlet include the Talcottville Cemetery Association, Fox Den Monuments LLC, Karpinski Water Supply, and portions of three active dairy farms.
The author and critic Edmund Wilson was a summer resident, and wrote Upstate: Records and Recollections of Northern New York (New York: Farrar, Straus & Giroux, 1971; reprint, Syracuse: Syracuse University Press, 1990), a memoir of his time in Talcottville.