| Takashi Sugimura | |
| Birth Date: | April 20, 1926 |
| Birth Place: | Tokyo, Japan |
| Death Date: | September 6, 2020 (aged 94) |
| Field: | Biochemistry Cancer Research |
| Work Institutions: | National Cancer Center University of Tokyo Japanese Foundation for Cancer Research |
| Alma Mater: | University of Tokyo |
| Known For: | Carcinogenesis |
| Prizes: | Charles S. Mott Prize (1981) Japan Prize (1997) |
was a Japanese biochemist, famous for research on chemical carcinogens. He received the Japan Prize for the contribution to establishment of fundamental concept on causes of cancer.[1] He was elected as President of the Japan Academy on October 15, 2013,[2] serving till 2016 and was replaced with Hiroshi Shiono.[3]
Sugimura isolated and identified many mutagens with a structure of heterocyclic amine from foods cooked under ordinary conditions. He showed that tumors induced by these heterocyclic amines had genetic alterations. He further developed his studies to analyze multiple-step carcinogenesis at molecular levels to promote effective primary prevention of cancer.[4] His group identified the novel polymer poly(ADP-ribose) and demonstrated the presence of the enzyme poly ADP ribose polymerase (PARP). He also discovered the cognate catabolic enzyme, poly(ADP-ribose) glycohydrolase (PARG) and further elucidated the biology of poly(ADP-ribose). The discovery of pierisin, an apoptogenic peptide that ADP-ribosylates DNA, profoundly illuminates his scientific character and curiosity as well.[5]
Sugimura completed his M.D. in 1949 from the Faculty of Medicine, University of Tokyo, and received the degree of Doctor of Medical Science in 1957 from the same institution.[1] After his postdoctoral fellowship at the Cancer Institute, Japanese Foundation for Cancer Research, he became Chief of Biochemistry Division at the Research Institute, National Cancer Center in Tokyo in 1962, where he served as President from 1984 to 1991.[6] In addition, he was Professor of Institute of Medical Science, University of Tokyo from 1970 to 1985 and President of Toho University from 1994 to 2000.[6] He was Fellow of the American Association for Cancer Research (AACR) Academy,[4] Honorary Member of Japanese Cancer Association[7] and also President Emeritus of National Cancer Center.
Sugimura received numerous awards and honors which include the following: