Tagatose-bisphosphate aldolase explained

tagatose-bisphosphate aldolase
Ec Number:	4.1.2.40
Cas Number:	39433-95-9
Go Code:	0009025

The enzyme tagatose-bisphosphate aldolase catalyzes the chemical reaction

D-tagatose 1,6-bisphosphate

\rightleftharpoons glycerone phosphate^[1] + Dglyceraldehyde 3-phosphate

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is D-tagatose 1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming). This enzyme is also called D-tagatose-1,6-bisphosphate triosephosphate lyase. This enzyme participates in galactose metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Book: Anderson RL, Markwell JP . D-Tagatose-1,6-bisphosphate aldolase (Class II) from Klebsiella pneumoniae . 1982 . Carbohydrate Metabolism - Part E . Methods Enzymol. . 90 . 323 - 324 . 6759854 . 10.1016/s0076-6879(82)90131-8. 978-0-12-181990-3 .
• van Rooijen RJ, van Schalkwijk S, de Vos WM . 1991 . Molecular cloning, characterization, and nucleotide sequence of the tagatose 6-phosphate pathway gene cluster of the lactose operon of Lactococcus lactis . J. Biol. Chem. . 266 . 7176 - 81 . 1901863 . 11 . 10.1016/S0021-9258(20)89626-4 . free .

Notes and References

1. Commonly known as dihydroxyacetone phosphate.