Tabersonine 16-O-methyltransferase explained

11-O-demethyl-17-O-deacetylvindoline O-methyltransferase
Ec Number:	2.1.1.94
Cas Number:	100984-95-0
Go Code:	0030766

In enzymology, a tabersonine 16-O-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 16-hydroxytabersonine

\rightleftharpoons S-adenosyl-L-homocysteine + 16-methoxytabersonine

Thus, the two substrates of this enzyme are S-adenosyl methionine and 16-hydroxytabersonine, whereas its two products are S-adenosylhomocysteine and 16-methoxytabersonine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase. Other names in common use include 11-demethyl-17-deacetylvindoline 11-methyltransferase, 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase, S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline, and 11-O-methyltransferase. This enzyme participates in terpene indole and ipecac alkaloid biosynthesis.

References

• Foucher AL, McIntosh A, Douce G, Wastling J, Tait A, Turner CM . 2006 . A proteomic analysis of arsenical drug resistance in Trypanosoma brucei . Proteomics . 6 . 2726 - 32 . 16526094 . 10.1002/pmic.200500419 . 9 .
• Fahn W, Laussermair E, Deus-Neumann B, Stockigt J . 1985 . Late enzymes of vindoline biosynthesis S-Adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methylase and unspecific acetylesterase . Plant Cell Rep. . 4 . 337 - 340 . 10.1007/bf00269893.