Tabernanthine Explained

Tabernanthine is an alkaloid found in Tabernanthe iboga.^[1]

It has been used in laboratory experiments to study how addiction affects the brain.^[2]

Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.^[3]

Pharmacology

It is kappa opioid agonist (K_i = 0.15 μM) and NMDA receptor (K_i = 10.5 μM) antagonist.^{[4] [5]} Compared to ibogaine, it binds weakly to σ₁ and σ₂ receptor.

See also

• Coronaridine
• Ibogamine
• Voacangine
• Tabernaemontanine
• Tabernanthalog

Notes and References

1. The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine . Journal of the American Chemical Society. 80. 126–136. 10.1021/ja01534a036 . 1958. Bartlett MF, Dickel DF, Taylor WI .
2. Levi MS, Borne RF . A review of chemical agents in the pharmacotherapy of addiction . Current Medicinal Chemistry . 9 . 20 . 1807–1818 . October 2002 . 12369879 . 10.2174/0929867023368980 .
3. Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW, Carlson JN . Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum . Brain Research . 657 . 1–2 . 14–22 . September 1994 . 7820611 . 10.1016/0006-8993(94)90948-2 . 1940631 .
4. Deecher DC, Teitler M, Soderlund DM, Bornmann WG, Kuehne ME, Glick SD . Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies . Brain Research . 571 . 2 . 242–247 . February 1992 . 1377086 . 10.1016/0006-8993(92)90661-r . 17159661 .
5. Book: Wiart C . Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases. 16 December 2013. Academic Press. 978-0-12-398383-1. 67–69, 73.