Tabernaemontana corymbosa explained

Tabernaemontana corymbosa is a species of plant in the family Apocynaceae. It is native to Brunei, China, Indonesia, Laos, Malaysia, Myanmar, Singapore, Thailand, and Vietnam. Glossy green leaves and faintly sweet scented flower. Flowers continuously all year. Frost tolerant. Grows to about 2 metres. Likes full sun to part shade. A number of cultivars are available.

Chemical composition

Multiple compounds of different classes such as Iboga alkaloids and Bisindole alkaloids have been isolated from this plant. Alkaloids such as conodusine A-E, conolodinines A-D, conophylline, conophyllinine and taberyunines A-I are present in which many shows antiproliferative and cytotoxic actions.^{[1] [2] [3] [4]}

Notes and References

1. Zhang Y, Ding X, Yuan YX, Guo LL, Hao XJ . Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification . . 83 . 5 . 1432–1439 . May 2020 . 32356659 . 10.1021/acs.jnatprod.9b00856 . 218474047 .
2. Sim DS, Navanesan S, Sim KS, Gurusamy S, Lim SH, Low YY, Kam TS . Conolodinines A-D, Aspidosperma- Aspidosperma Bisindole Alkaloids with Antiproliferative Activity from Tabernaemontana corymbosa . . 82 . 4 . 850–858 . April 2019 . 30869890 . 10.1021/acs.jnatprod.8b00919 . 78093751 .
3. Zhang BJ, Lu JS, Bao MF, Zhong XH, Ni L, Wu J, Cai XH . Bisindole alkaloids from Tabernaemontana corymbosa . . 152 . 125–133 . August 2018 . 29758521 . 10.1016/j.phytochem.2018.04.020 . 21727496 .
4. Nge CE, Chong KW, Thomas NF, Lim SH, Low YY, Kam TS . Ibogan, Aspidosperman, Vincamine, and Bisindole Alkaloids from a Malayan Tabernaemontana corymbosa: Iboga Alkaloids with C-20α Substitution . . 79 . 5 . 1388–99 . May 2016 . 27077800 . 10.1021/acs.jnatprod.6b00129 .