TXNIP explained

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.^{[1] [2]}

Interactions

TXNIP has been shown to interact with Thioredoxin^[3] and ZBTB32.^[4]

Related gene problems

• TAR syndrome
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

Further reading

• Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J . Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression . The Journal of Biological Chemistry . 274 . 31 . 21645–50 . Jul 1999 . 10419473 . 10.1074/jbc.274.31.21645 . free.
• Ludwig DL, Kotanides H, Le T, Chavkin D, Bohlen P, Witte L . Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene . Gene . 269 . 1–2 . 103–12 . May 2001 . 11376942 . 10.1016/S0378-1119(01)00455-3.
• Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ . Positional cloning of the combined hyperlipidemia gene Hyplip1 . Nature Genetics . 30 . 1 . 110–6 . Jan 2002 . 11753387 . 2846781 . 10.1038/ng811.
• Joguchi A, Otsuka I, Minagawa S, Suzuki T, Fujii M, Ayusawa D . Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat . Biochemical and Biophysical Research Communications . 293 . 1 . 293–7 . Apr 2002 . 12054598 . 10.1016/S0006-291X(02)00208-5.
• Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM . The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin . Proceedings of the National Academy of Sciences of the United States of America . 99 . 18 . 11700–5 . Sep 2002 . 12189205 . 129332 . 10.1073/pnas.182372299 . 2002PNAS...9911700B . free.
• Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT . Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin . Circulation Research . 91 . 8 . 689–95 . Oct 2002 . 12386145 . 10.1161/01.RES.0000037982.55074.F6 . free.
• Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I . VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression . Oncogene . 22 . 26 . 4035–46 . Jun 2003 . 12821938 . 10.1038/sj.onc.1206610 . free.
• Champliaud MF, Viel A, Baden HP . The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes . The Journal of Investigative Dermatology . 121 . 4 . 781–5 . Oct 2003 . 14632196 . 10.1046/j.1523-1747.2003.12539.x . free.
• Kim KY, Shin SM, Kim JK, Paik SG, Yang Y, Choi I . Heat shock factor regulates VDUP1 gene expression . Biochemical and Biophysical Research Communications . 315 . 2 . 369–75 . Mar 2004 . 14766217 . 10.1016/j.bbrc.2004.01.047.
• Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT . Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein . The Journal of Biological Chemistry . 279 . 29 . 30369–74 . Jul 2004 . 15128745 . 10.1074/jbc.M400549200 . free.
• Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA, Hopkins PN, Weiss R, Hunt SC, Leppert MF . TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study . Atherosclerosis . 174 . 2 . 357–62 . Jun 2004 . 15136067 . 10.1016/j.atherosclerosis.2004.02.004.
• Nishinaka Y, Masutani H, Oka S, Matsuo Y, Yamaguchi Y, Nishio K, Ishii Y, Yodoi J . Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1 . The Journal of Biological Chemistry . 279 . 36 . 37559–65 . Sep 2004 . 15234975 . 10.1074/jbc.M405473200 . free.
• Aitken CJ, Hodge JM, Nishinaka Y, Vaughan T, Yodoi J, Day CJ, Morrison NA, Nicholson GC . Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling . Journal of Bone and Mineral Research . 19 . 12 . 2057–64 . Dec 2004 . 15537450 . 10.1359/JBMR.040913 . 26600161 . free.
• Yamawaki H, Pan S, Lee RT, Berk BC . Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells . The Journal of Clinical Investigation . 115 . 3 . 733–8 . Mar 2005 . 15696199 . 546457 . 10.1172/JCI23001.
• Minn AH, Hafele C, Shalev A . Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis . Endocrinology . 146 . 5 . 2397–405 . May 2005 . 15705778 . 10.1210/en.2004-1378 . free.

Notes and References

1. Chen KS, DeLuca HF . Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3 . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1219 . 1 . 26–32 . Sep 1994 . 8086474 . 10.1016/0167-4781(94)90242-9 .
2. Web site: Entrez Gene: TXNIP thioredoxin interacting protein.
3. Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J . Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression . The Journal of Biological Chemistry . 274 . 31 . 21645–50 . Jul 1999 . 10419473 . 10.1074/jbc.274.31.21645 . free .
4. Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I . VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression . Oncogene . 22 . 26 . 4035–46 . Jun 2003 . 12821938 . 10.1038/sj.onc.1206610 . free .