TXNDC5 explained

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.^[1]

Function

This gene encodes a protein disulfide-isomerase.^[2] Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.

Further reading

• Neve EP, Svensson K, Fuxe J, Pettersson RF . VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum . Experimental Cell Research . 288 . 1 . 70–83 . Aug 2003 . 12878160 . 10.1016/S0014-4827(03)00161-7 .
• Knoblach B, Keller BO, Groenendyk J, Aldred S, Zheng J, Lemire BD, Li L, Michalak M . ERp19 and ERp46, new members of the thioredoxin family of endoplasmic reticulum proteins . Molecular & Cellular Proteomics . 2 . 10 . 1104–19 . Oct 2003 . 12930873 . 10.1074/mcp.M300053-MCP200 . free .
• Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R . EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor . The Journal of Biological Chemistry . 278 . 47 . 47079–88 . Nov 2003 . 12963716 . 10.1074/jbc.M308124200 . free .
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B . Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis . Proteomics . 5 . 15 . 3876–84 . Oct 2005 . 16130169 . 10.1002/pmic.200401239 . 26007149 .
• Nissom PM, Lo SL, Lo JC, Ong PF, Lim JW, Ou K, Liang RC, Seow TK, Chung MC . Hcc-2, a novel mammalian ER thioredoxin that is differentially expressed in hepatocellular carcinoma . FEBS Letters . 580 . 9 . 2216–26 . Apr 2006 . 16574106 . 10.1016/j.febslet.2006.03.029 . 1344909 . free .
• Wang Y, Ma Y, Lü B, Xu E, Huang Q, Lai M . Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study . Experimental Biology and Medicine . 232 . 9 . 1152–9 . Oct 2007 . 17895523 . 10.3181/0701-RM-8 . 42784486 .

Notes and References

1. Web site: Entrez Gene: TXNDC5 thioredoxin domain containing 5.
2. Galligan JJ, Petersen DR . The human protein disulfide isomerase gene family . Human Genomics . 6 . 6 . 6 . July 2012 . 23245351 . 3500226 . 10.1186/1479-7364-6-6 . free .