ERP44 explained

Endoplasmic reticulum resident protein 44 (ERp44) also known as thioredoxin domain-containing protein 4 (TXNDC4) is a protein that in humans is encoded by the ERP44 gene.^{[1] [2] [3]}

Interactions

TXNDC4 has been shown to interact with ERO1L.^[3]

Further reading

• Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C, Sitia R . Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis . The EMBO Journal . 26 . 19 . 4177–88 . Oct 2007 . 17805346 . 2230840 . 10.1038/sj.emboj.7601844 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Otsu M, Bertoli G, Fagioli C, Guerini-Rocco E, Nerini-Molteni S, Ruffato E, Sitia R . Dynamic retention of Ero1alpha and Ero1beta in the endoplasmic reticulum by interactions with PDI and ERp44 . Antioxidants & Redox Signaling . 8 . 3–4 . 274–82 . 2006 . 16677073 . 10.1089/ars.2006.8.274 .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Higo T, Hattori M, Nakamura T, Natsume T, Michikawa T, Mikoshiba K . Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44 . Cell . 120 . 1 . 85–98 . Jan 2005 . 15652484 . 10.1016/j.cell.2004.11.048 . 12398022 . free .
• Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP . Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46 . The Journal of Biological Chemistry . 279 . 45 . 47242–53 . Nov 2004 . 15308636 . 10.1074/jbc.M406644200 . free .
• Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Camerini S, Mezghrani A, Ruffato E, Simmen T, Sitia R . Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44 . The EMBO Journal . 22 . 19 . 5015–22 . Oct 2003 . 14517240 . 204474 . 10.1093/emboj/cdg491 .
• O'Neill EE, Brock CJ, von Kriegsheim AF, Pearce AC, Dwek RA, Watson SP, Hebestreit HF . Towards complete analysis of the platelet proteome . Proteomics . 2 . 3 . 288–305 . Mar 2002 . 11921445 . 10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0 . 20643741 .
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 1 . 31–9 . Feb 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .

Notes and References

1. Anelli T, Alessio M, Mezghrani A, Simmen T, Talamo F, Bachi A, Sitia R . ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family . The EMBO Journal . 21 . 4 . 835–44 . Feb 2002 . 11847130 . 125352 . 10.1093/emboj/21.4.835 .
2. Web site: Entrez Gene: TXNDC4 thioredoxin domain containing 4 (endoplasmic reticulum).
3. Galligan JJ, Petersen DR . The human protein disulfide isomerase gene family . Human Genomics . 6 . 6. July 2012 . 23245351 . 3500226 . 10.1186/1479-7364-6-6 . 1 . free .