TXNDC12 explained

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.^{[1] [2] [3]}

TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors^[4] (Liu et al., 2003).[supplied by OMIM]

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Alanen HI, Williamson RA, Howard MJ, etal . Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member. . J. Biol. Chem. . 278 . 31 . 28912–20 . 2003 . 12761212 . 10.1074/jbc.M304598200 . free .
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 .
• Liu F, Rong YP, Zeng LC, etal . Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. . Gene . 315 . 71–8 . 2004 . 14557066 . 10.1016/S0378-1119(03)00732-7 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .

Notes and References

1. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal Biochem . 236 . 1 . 107–13 . Jun 1996 . 8619474 . 10.1006/abio.1996.0138 .
2. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res . 7 . 4 . 353–8 . Jun 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353.
3. Web site: Entrez Gene: TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum).
4. Galligan JJ, Petersen DR . The human protein disulfide isomerase gene family . Human Genomics . 6 . 6 . 6 . July 2012 . 23245351 . 3500226 . 10.1186/1479-7364-6-6 . free .