TWSG1 explained

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.^{[1] [2]} The protein is a binding protein for bone morphogenetic proteins, similar to Chordin.^[3] The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.^[4]

Further reading

• Graf D, Nethisinghe S, Palmer DB, etal . The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. . J. Exp. Med. . 196 . 2 . 163–71 . 2002 . 12119341 . 10.1084/jem.20020276 . 2193926 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Zakin L, De Robertis EM . Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. . Development . 131 . 2 . 413–24 . 2004 . 14681194 . 10.1242/dev.00946 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Moreno M, Muñoz R, Aroca F, etal . Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway. . EMBO J. . 24 . 7 . 1397–405 . 2005 . 15775969 . 10.1038/sj.emboj.7600615 . 1142540 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Tzachanis D, Li L, Lafuente EM, etal . Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. . Blood . 109 . 7 . 2944–52 . 2007 . 17164348 . 10.1182/blood-2006-03-006510 . 1852213 .

Notes and References

1. Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS . Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling . Nature . 410 . 6827 . 475–8 . Mar 2001 . 11260715 . 10.1038/35068572 . 4392365 .
2. Web site: Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila).
3. Oelgeschläger M, Larraín J, Geissert D, De Robertis EM . The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. . Nature . 405 . 6788 . 757–63 . 2000 . 10866189 . 10.1038/35015500 . 2292104 . 2000Natur.405..757O .
4. Graf . D. . Timmons . P. M. . Hitchins . M. . Episkopou . V. . Moore . G. . Ito . T. . Fujiyama . A. . Fisher . A. G. . Merkenschlager . M. . Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation . Mammalian Genome . July 2001 . 12 . 7 . 554–560 . 10.1007/s0033501-0005-x . 11420619 . 36371559 . 6 March 2023 . 0938-8990.