TWF1 explained

Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene.^{[1] [2]} This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.^[2]

Further reading

• Palmgren S, Vartiainen M, Lappalainen P . Twinfilin, a molecular mailman for actin monomers. . J. Cell Sci. . 115 . Pt 5 . 881–6 . 2002 . 10.1242/jcs.115.5.881 . 11870207 .
• Hassel S, Eichner A, Yakymovych M, etal . Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. . Proteomics . 4 . 5 . 1346–58 . 2004 . 15188402 . 10.1002/pmic.200300770 . 6773754 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Vartiainen MK, Sarkkinen EM, Matilainen T, etal . Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. . J. Biol. Chem. . 278 . 36 . 34347–55 . 2003 . 12807912 . 10.1074/jbc.M303642200 . free .
• Galey D, Becker K, Haughey N, etal . Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. . J. Neurovirol. . 9 . 3 . 358–71 . 2003 . 12775419 . 10.1080/13550280390201119 . 22016092 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ojala PJ, Paavilainen VO, Vartiainen MK, etal . The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers. . Mol. Biol. Cell . 13 . 11 . 3811–21 . 2003 . 12429826 . 10.1091/mbc.E02-03-0157 . 133594 .
• Paavilainen VO, Merckel MC, Falck S, etal . Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. . J. Biol. Chem. . 277 . 45 . 43089–95 . 2003 . 12207032 . 10.1074/jbc.M208225200 . free .

Notes and References

1. Beeler JF, LaRochelle WJ, Chedid M, Tronick SR, Aaronson SA . Prokaryotic expression cloning of a novel human tyrosine kinase . Mol. Cell. Biol. . 14 . 2 . 982–8 . February 1994 . 10.1128/mcb.14.2.982 . 7507208 . 358453 .
2. Web site: Entrez Gene: TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila).