TUB (gene) explained

Tubby protein homolog is a protein that in humans is encoded by the TUB gene.^{[1] [2]}

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.

Interactions

TUB (gene) has been shown to interact with PLCG1.^[3]

Further reading

• Ikeda A, Nishina PM, Naggert JK . The tubby-like proteins, a family with roles in neuronal development and function. . J. Cell Sci. . 115 . Pt 1 . 9–14 . 2002 . 10.1242/jcs.115.1.9 . 11801719 . free .
• Jones JM, Meisler MH, Seldin MF, etal . Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7. . Genomics . 14 . 1 . 197–9 . 1992 . 1358794 . 10.1016/S0888-7543(05)80308-8 . 2027.42/29864 . free .
• North MA, Naggert JK, Yan Y, etal . Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. . Proc. Natl. Acad. Sci. U.S.A. . 94 . 7 . 3128–33 . 1997 . 9096357 . 10.1073/pnas.94.7.3128 . 20333 . 1997PNAS...94.3128N . free .
• Kapeller R, Moriarty A, Strauss A, etal . Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin. . J. Biol. Chem. . 274 . 35 . 24980–6 . 1999 . 10455176 . 10.1074/jbc.274.35.24980 . free .
• Boggon TJ, Shan WS, Santagata S, etal . Implication of tubby proteins as transcription factors by structure-based functional analysis. . Science . 286 . 5447 . 2119–25 . 1999 . 10591637 . 10.1126/science.286.5447.2119 . 33506220 .
• He W, Ikeda S, Bronson RT, etal . GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members. . Brain Res. Mol. Brain Res. . 81 . 1–2 . 109–17 . 2001 . 11000483 . 10.1016/S0169-328X(00)00164-9 .
• Santagata S, Boggon TJ, Baird CL, etal . G-protein signaling through tubby proteins. . Science . 292 . 5524 . 2041–50 . 2001 . 11375483 . 10.1126/science.1061233 . 29856557 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Shiri-Sverdlov R, Custers A, van Vliet-Ostaptchouk JV, etal . Identification of TUB as a novel candidate gene influencing body weight in humans. . Diabetes . 55 . 2 . 385–9 . 2006 . 16443771 . 10.2337/diabetes.55.02.06.db05-0997 . free .
• Giannaccini G, Giusti L, Santini F, etal . Tubby protein in human lymphocytes from normal weight and obese subjects. . Clin. Biochem. . 40 . 11 . 806–9 . 2007 . 17498679 . 10.1016/j.clinbiochem.2007.03.020 .

Notes and References

1. Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC, Wu Y, Berkemeier LR, Misumi DJ, Holmgren L, Charlat O, Woolf EA, Tayber O, Brody T, Shu P, Hawkins F, Kennedy B, Baldini L, Ebeling C, Alperin GD, Deeds J, Lakey ND, Culpepper J, Chen H, Glucksmann-Kuis MA, Carlson GA, Duyk GM, Moore KJ . Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family . Cell . 85 . 2 . 281–90 . Jun 1996 . 8612280 . 10.1016/S0092-8674(00)81104-6 . 15670925 . free .
2. Web site: Entrez Gene: TUB tubby homolog (mouse).
3. 10.1074/jbc.274.35.24980 . Kapeller . R . Moriarty A . Strauss A . Stubdal H . Theriault K . Siebert E . Chickering T . Morgenstern J P . Tartaglia L A . Lillie J . Aug 1999 . Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin . J. Biol. Chem. . 274 . 35 . 24980–6 . UNITED STATES. 0021-9258. 10455176 . free .