TUBG1 explained

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene.^[1] This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle.

Further reading

• Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C . Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome . Journal of Cell Science . 122 . Pt 13 . 2240–51 . July 2009 . 19509060 . 10.1242/jcs.042747 . free .
• Lau AS, Mruk DD . Rab8B GTPase and junction dynamics in the testis . Endocrinology . 144 . 4 . 1549–63 . April 2003 . 12639940 . 10.1210/en.2002-220893 . free .
• Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA . LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome . Neuron . 28 . 3 . 665–79 . December 2000 . 11163258 . 10.1016/S0896-6273(00)00145-8 . 15923472 . free .
• Hsu LC, White RL . BRCA1 is associated with the centrosome during mitosis . Proceedings of the National Academy of Sciences of the United States of America . 95 . 22 . 12983–8 . October 1998 . 9789027 . 23679 . 10.1073/pnas.95.22.12983 . free .
• Manning JA, Shalini S, Risk JM, Day CL, Kumar S . A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome . PLOS ONE . 5 . 3 . e9618 . March 2010 . 20224777 . 2835750 . 10.1371/journal.pone.0009618 . Hotchin . Neil A . free .
• Aldaz H, Rice LM, Stearns T, Agard DA . Insights into microtubule nucleation from the crystal structure of human gamma-tubulin . Nature . 435 . 7041 . 523–7 . May 2005 . 15917813 . 10.1038/nature03586 . 4388646 .
• Niu Y, Liu T, Tse GM, Sun B, Niu R, Li HM, Wang H, Yang Y, Ye X, Wang Y, Yu Q, Zhang F . Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast . Cancer Science . 100 . 4 . 580–7 . April 2009 . 19215229 . 10.1111/j.1349-7006.2008.01075.x . 205234685 . free . 11158874 .
• Hampe C, Ardila-Osorio H, Fournier M, Brice A, Corti O . Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity . Human Molecular Genetics . 15 . 13 . 2059–75 . July 2006 . 16714300 . 10.1093/hmg/ddl131 . free .
• Zyss D, Montcourrier P, Vidal B, Anguille C, Mérezègue F, Sahuquet A, Mangeat PH, Coopman PJ . The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression . Cancer Research . 65 . 23 . 10872–80 . December 2005 . 16322234 . 10.1158/0008-5472.CAN-05-1270 . free .

Notes and References

1. Web site: Entrez Gene: Tubulin, gamma 1 .