TUBB1 explained

TUBB1 is a gene that codes for the protein Tubulin beta-1 chain in humans.^[1]

Further reading

• Watts NR, Sackett DL, Ward RD, etal . HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings . J. Cell Biol. . 150 . 2 . 349–60 . 2000 . 10908577 . 10.1083/jcb.150.2.349 . 2180222 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Andersen JS, Lyon CE, Fox AH, etal . Directed proteomic analysis of the human nucleolus . Curr. Biol. . 12 . 1 . 1–11 . 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Chen D, Wang M, Zhou S, Zhou Q . HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim . EMBO J. . 21 . 24 . 6801–10 . 2004 . 12486001 . 10.1093/emboj/cdf683 . 139103 .
• Gevaert K, Goethals M, Martens L, etal . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Yanagida M, Hayano T, Yamauchi Y, etal . Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes . J. Biol. Chem. . 279 . 3 . 1607–14 . 2004 . 14583623 . 10.1074/jbc.M305604200 . free .
• Dou Z, Ding X, Zereshki A, etal . TTK kinase is essential for the centrosomal localization of TACC2 . FEBS Lett. . 572 . 1–3 . 51–6 . 2004 . 15304323 . 10.1016/j.febslet.2004.06.092 . 8403635 .
• Schulze H, Korpal M, Bergmeier W, etal . Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions . Blood . 104 . 13 . 3949–57 . 2005 . 15315966 . 10.1182/blood-2004-03-1179 . free .
• Campbell GR, Pasquier E, Watkins J, etal . The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis . J. Biol. Chem. . 279 . 46 . 48197–204 . 2005 . 15331610 . 10.1074/jbc.M406195200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• de Mareuil J, Carre M, Barbier P, etal . HIV-1 Tat protein enhances Microtubule polymerization . Retrovirology . 2 . 5 . 2006 . 15691386 . 10.1186/1742-4690-2-5 . 549075 . free .
• Giacca M . HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? . Retrovirology . 2 . 7 . 2006 . 15698476 . 10.1186/1742-4690-2-7 . 549042 . free .
• Freson K, De Vos R, Wittevrongel C, etal . The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure . Blood . 106 . 7 . 2356–62 . 2005 . 15956286 . 10.1182/blood-2005-02-0723 . free .
• Mesquita B, Veiga I, Pereira D, etal . No significant role for beta tubulin mutations and mismatch repair defects in ovarian cancer resistance to paclitaxel/cisplatin . BMC Cancer . 5. 101 . 2006 . 16095531 . 10.1186/1471-2407-5-101 . 1199587 . free .
• Coiras M, Camafeita E, Ureña T, etal . Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression . Proteomics . 6 . S63–73 . 2006. Suppl 1 . 16526095 . 10.1002/pmic.200500437 . 42878271 .
• Navarro-Núñez L, Lozano ML, Rivera J, etal . The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men . Haematologica . 92 . 4 . 513–8 . 2007 . 17488662 . 10.3324/haematol.10689 . free .

Notes and References

1. Web site: Entrez Gene: TUBB1 tubulin, beta 1.