TUBB explained

Tubulin beta chain is a protein that in humans is encoded by the TUBB gene.^{[1] [2] [3]}

Interactions

TUBB has been shown to interact with NCOA6^[4] and SYT9.^[5]

See also

• Tubulin

References

Further reading

• Berrieman HK, Lind MJ, Cawkwell L . Do beta-tubulin mutations have a role in resistance to chemotherapy? . The Lancet. Oncology . 5 . 3 . 158–64 . Mar 2004 . 15003198 . 10.1016/S1470-2045(04)01411-1 .
• Horisberger MA . Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins . Journal of Virology . 66 . 8 . 4705–9 . Aug 1992 . 1629950 . 241296 . 10.1128/JVI.66.8.4705-4709.1992.
• Wang D, Villasante A, Lewis SA, Cowan NJ . The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype . The Journal of Cell Biology . 103 . 5 . 1903–10 . Nov 1986 . 3782288 . 2114403 . 10.1083/jcb.103.5.1903 .
• Lee MG, Lewis SA, Wilde CD, Cowan NJ . Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes . Cell . 33 . 2 . 477–87 . Jun 1983 . 6688039 . 10.1016/0092-8674(83)90429-4 . free .
• Hall JL, Dudley L, Dobner PR, Lewis SA, Cowan NJ . Identification of two human beta-tubulin isotypes . Molecular and Cellular Biology . 3 . 5 . 854–62 . May 1983 . 6865944 . 368608 . 10.1128/mcb.3.5.854.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . Apr 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . Apr 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Kinnunen T, Kaksonen M, Saarinen J, Kalkkinen N, Peng HB, Rauvala H . Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth . The Journal of Biological Chemistry . 273 . 17 . 10702–8 . Apr 1998 . 9553134 . 10.1074/jbc.273.17.10702 . free .
• Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M . CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90 . Neuron . 20 . 4 . 693–707 . Apr 1998 . 9581762 . 10.1016/S0896-6273(00)81009-0 . 16068361 . free .
• Rasmussen RK, Ji H, Eddes JS, Moritz RL, Reid GE, Simpson RJ, Dorow DS . Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins . Electrophoresis . 19 . 5 . 809–17 . May 1998 . 9629920 . 10.1002/elps.1150190535 . 21204230 .
• Ciruela F, Robbins MJ, Willis AC, McIlhinney RA . Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin . Journal of Neurochemistry . 72 . 1 . 346–54 . Jan 1999 . 9886087 . 10.1046/j.1471-4159.1999.0720346.x . 3923065 . free .
• Chau MF, Radeke MJ, de Inés C, Barasoain I, Kohlstaedt LA, Feinstein SC . The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains . Biochemistry . 37 . 51 . 17692–703 . Dec 1998 . 9922135 . 10.1021/bi9812118 .
• Piredda L, Farrace MG, Lo Bello M, Malorni W, Melino G, Petruzzelli R, Piacentini M . Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis . FASEB Journal . 13 . 2 . 355–64 . Feb 1999 . 9973324 . 10.1096/fasebj.13.2.355. 16417170 . free .
• Feng Y, Hodge DR, Palmieri G, Chase DL, Longo DL, Ferris DK . Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex . The Biochemical Journal . 339 . 2 . 435–42 . Apr 1999 . 10191277 . 1220175 . 10.1042/0264-6021:3390435 .
• Martín L, Fanarraga ML, Aloria K, Zabala JC . Tubulin folding cofactor D is a microtubule destabilizing protein . FEBS Letters . 470 . 1 . 93–5 . Mar 2000 . 10722852 . 10.1016/S0014-5793(00)01293-X . 35012741 . free . 2000FEBSL.470...93M .
• Tarazona R, López-Lluch G, Galiani MD, Aguado E, Barahona F, Solana R, Peña J . HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity . Journal of Immunology . 165 . 12 . 6776–82 . Dec 2000 . 11120798 . 10.4049/jimmunol.165.12.6776 . free .
• Bonnet C, Boucher D, Lazereg S, Pedrotti B, Islam K, Denoulet P, Larcher JC . Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation . The Journal of Biological Chemistry . 276 . 16 . 12839–48 . Apr 2001 . 11278895 . 10.1074/jbc.M011380200 . free .
• Ivings L, Pennington SR, Jenkins R, Weiss JL, Burgoyne RD . Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin . The Biochemical Journal . 363 . Pt 3 . 599–608 . May 2002 . 11964161 . 1222513 . 10.1042/0264-6021:3630599 .

Notes and References

1. Crabtree DV, Ojima I, Geng X, Adler AJ . Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site . Bioorganic & Medicinal Chemistry . 9 . 8 . 1967–76 . Aug 2001 . 11504633 . 10.1016/S0968-0896(01)00103-1 .
2. Volz A, Weiss E, Trowsdale J, Ziegler A . Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction . Human Genetics . 93 . 1 . 42–6 . Jan 1994 . 8270253 . 10.1007/BF00218911 . 7853030 .
3. Web site: Entrez Gene: TUBB tubulin, beta.
4. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW . Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins . Molecular and Cellular Biology . 23 . 1 . 140–9 . Jan 2003 . 12482968 . 140670 . 10.1128/MCB.23.1.140-149.2003 .
5. Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R . Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules . Journal of Cell Science . 116 . Pt 21 . 4307–18 . Nov 2003 . 12966166 . 10.1242/jcs.00719 . free .