TUBA1B explained

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.^{[1] [2] [3]}

Interactions

TUBA1B has been shown to interact with PIK3R1.^[4] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.^[5]

Further reading

• Venter JC . Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing. . 45 . J. Pharm. Pharmacol. . Suppl 1 . 355–60 . 1993 . 8098743 .
• Lopez-Fanarraga M, Avila J, Guasch A, etal . Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. . J. Struct. Biol. . 135 . 2 . 219–29 . 2002 . 11580271 . 10.1006/jsbi.2001.4386 .
• Kapeller R, Toker A, Cantley LC, Carpenter CL . Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. . J. Biol. Chem. . 270 . 43 . 25985–91 . 1995 . 7592789 . 10.1074/jbc.270.43.25985 . free .
• Alexandrova N, Niklinski J, Bliskovsky V, etal . The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. . Mol. Cell. Biol. . 15 . 9 . 5188–95 . 1995 . 7651436 . 10.1128/mcb.15.9.5188. 230766 .
• Szasz J, Yaffe MB, Sternlicht H . Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region. . Biophys. J. . 64 . 3 . 792–802 . 1993 . 8097117 . 10.1016/S0006-3495(93)81440-1 . 1262393 . 1993BpJ....64..792S .
• Baumann MH, Wisniewski T, Levy E, etal . C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. . Biochem. Biophys. Res. Commun. . 219 . 1 . 238–42 . 1996 . 8619814 . 10.1006/bbrc.1996.0211 . free .
• Gress TM, Müller-Pillasch F, Geng M, etal . A pancreatic cancer-specific expression profile. . Oncogene . 13 . 8 . 1819–30 . 1996 . 8895530 .
• Crépieux P, Kwon H, Leclerc N, etal . I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. . Mol. Cell. Biol. . 17 . 12 . 7375–85 . 1997 . 9372968 . 10.1128/mcb.17.12.7375. 232593 .
• Herreros L, Rodríguez-Fernandez JL, Brown MC, etal . Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton. . J. Biol. Chem. . 275 . 34 . 26436–40 . 2000 . 10840040 . 10.1074/jbc.M003970200 . free . 10261/135387 . free .
• Watts NR, Sackett DL, Ward RD, etal . HIV-1 rev depolymerizes microtubules to form stable bilayered rings. . J. Cell Biol. . 150 . 2 . 349–60 . 2000 . 10908577 . 10.1083/jcb.150.2.349 . 2180222 .
• Takeoka A, Shimizu M, Horio T . Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction. . 113 . J. Cell Sci. . Pt 24 . 4557–62 . 2001 . 24 . 10.1242/jcs.113.24.4557 . 11082048 .
• Germani A, Bruzzoni-Giovanelli H, Fellous A, etal . SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. . Oncogene . 19 . 52 . 5997–6006 . 2001 . 11146551 . 10.1038/sj.onc.1204002 . free .
• Yokota S, Yanagi H, Yura T, Kubota H . Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle. . Eur. J. Biochem. . 268 . 17 . 4664–73 . 2001 . 11532003 . 10.1046/j.1432-1327.2001.02393.x .
• Rommelaere H, De Neve M, Neirynck K, etal . Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. . J. Biol. Chem. . 276 . 44 . 41023–8 . 2001 . 11535601 . 10.1074/jbc.M106591200 . free .
• Klein C, Kramer EM, Cardine AM, etal . Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. . J. Neurosci. . 22 . 3 . 698–707 . 2002 . 11826099 . 6758498 . 10.1523/JNEUROSCI.22-03-00698.2002.
• Saugstad JA, Yang S, Pohl J, etal . Interaction between metabotropic glutamate receptor 7 and alpha tubulin. . J. Neurochem. . 80 . 6 . 980–8 . 2002 . 11953448 . 2925652 . 10.1046/j.0022-3042.2002.00778.x .

Notes and References

1. Banerjee A . Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells . Biochem Biophys Res Commun . 293 . 1 . 598–601 . Jun 2002 . 12054644 . 10.1016/S0006-291X(02)00269-3 .
2. Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW . Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions . Mol Cell Biol . 3 . 10 . 1738–45 . Jan 1984 . 6646120 . 370035 . 10.1128/mcb.3.10.1738.
3. Web site: Entrez Gene: TUBA1B tubulin, alpha 1b.
4. 10.1074/jbc.270.43.25985 . Kapeller . R . Toker A . Cantley L C . Carpenter C L . Oct 1995 . Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin . J. Biol. Chem. . 270 . 43 . 25985–91 . UNITED STATES. 0021-9258. 7592789 . free .
5. Web site: Anti-alpha Tubulin antibody [GT114] (GTX628802) | GeneTex.