TTI2 explained

TELO2 interacting protein 2 is a protein that is encoded by the TTI2 gene in humans.^[1]

Function

This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.

The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

Further reading

• Hurov KE, Cotta-Ramusino C, Elledge SJ . A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability . Genes Dev. . 24 . 17 . 1939–50 . 2010 . 20810650 . 2932975 . 10.1101/gad.1934210 .

Notes and References

1. Web site: Entrez Gene: TELO2 interacting protein 2. 2016-12-14.