TTF2 explained

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.^{[1] [2]}

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.

Interactions

TTF2 has been shown to interact with CDC5L.^[3]

Further reading

• Girdham CH, Glover DM . Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein . Genes & Development . 5 . 10 . 1786–99 . October 1991 . 1916263 . 10.1101/gad.5.10.1786 . free .
• Hara R, Selby CP, Liu M, Price DH, Sancar A . Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer . The Journal of Biological Chemistry . 274 . 35 . 24779–86 . August 1999 . 10455150 . 10.1074/jbc.274.35.24779 . free .
• Leonard D, Ajuh P, Lamond AI, Legerski RJ . hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing . Biochemical and Biophysical Research Communications . 308 . 4 . 793–801 . September 2003 . 12927788 . 10.1016/S0006-291X(03)01486-4 . 10.1.1.539.8359 .
• Jiang Y, Liu M, Spencer CA, Price DH . Involvement of transcription termination factor 2 in mitotic repression of transcription elongation . Molecular Cell . 14 . 3 . 375–85 . May 2004 . 15125840 . 10.1016/S1097-2765(04)00234-5 . free .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Jiang Y, Price DH . Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector . Cell Cycle . 3 . 9 . 1151–3 . September 2004 . 15467445 . 10.4161/cc.3.9.1151 . free .

Notes and References

1. Liu M, Xie Z, Price DH . A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member . The Journal of Biological Chemistry . 273 . 40 . 25541–4 . October 1998 . 9748214 . 10.1074/jbc.273.40.25541 . free .
2. Web site: Entrez Gene: TTF2 transcription termination factor, RNA polymerase II.
3. Leonard D, Ajuh P, Lamond AI, Legerski RJ . hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing . Biochemical and Biophysical Research Communications . 308 . 4 . 793–801 . September 2003 . 12927788 . 10.1016/S0006-291X(03)01486-4 . 10.1.1.539.8359 .