TTC4 explained

Tetratricopeptide repeat protein 4 is a protein that in humans is encoded by the TTC4 gene.^{[1] [2]}

The 34-amino acid tetratricopeptide repeat (TPR) motif is found in a variety of proteins and may mediate protein-protein or protein-membrane interactions.[supplied by OMIM]^[2]

Further reading

• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Lan S, Wang H, Jiang H, etal . Direct interaction between alpha-actinin and hepatitis C virus NS5B . FEBS Lett. . 554 . 3 . 289–94 . 2003 . 14623081 . 10.1016/S0014-5793(03)01163-3 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hey Y, Brintnell B, James LA, Varley JM . Assignment of TTC4 to human chromosome band 1p31.3 and a pseudogene TTC4P to 7p14→p13 by in situ hybridization . Cytogenet. Cell Genet. . 88 . 3–4 . 272–4 . 2000 . 10828607 . 10.1159/000015536 . 34754868 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .

Notes and References

1. Su G, Roberts T, Cowell JK . TTC4, a novel human gene containing the tetratricopeptide repeat and mapping to the region of chromosome 1p31 that is frequently deleted in sporadic breast cancer . Genomics . 55 . 2 . 157–63 . Sep 1999 . 9933562 . 10.1006/geno.1998.5633 .
2. Web site: Entrez Gene: TTC4 tetratricopeptide repeat domain 4.