TSUP family explained

The 4-Toluene Sulfonate Uptake Permease (TSUP) family (TC# 2.A.102) is also referred to as the TauE/SafE/YfcA/DUF81 Family.

Although its members have not been rigorously characterized, evidence is available that at least some members function in the transport of Sulfur containing Organic compounds. These include 4-toluene sulfonate which may be transported by the TsaS of Cupriavidus necator (TC# 2.A.102.1.1), sulfolactate which may be exported by the TauE protein of Cupriavidus necator (TC# 2.A.102.2.1) ^{[1] [2]} and sulfoacetate which may be exported by the SafE1 protein of Neptuniibacter caesariensis (TC# 2.A.102.2.2).^[3] Another member of the TSUP family, TsaS of Comamonas testosteroni, has been reported to function in the uptake of 4-toluene sulfonate.^[4] None of these functional assignments can be considered to be certain.^[5]

Further reading

• Locher. HH. Poolman. B. Cook. AM. Konings. WN. Uptake of 4-toluene sulfonate by Comamonas testosteroni T-2. Journal of Bacteriology . 1993. 175. 4. 1075–1080. 10.1128/jb.175.4.1075-1080.1993. 8432701. 193022.
• Mayer. J. Denger. K. Hollemeyer. K. Schleheck. D. Cook. AM. (R)-Cysteate-nitrogen assimilation by Cupriavidus necator H16 with excretion of 3-sulfolactate: a patchwork pathway.. Arch Microbiol. November 2012. 194. 11. 949–57. 10.1007/s00203-012-0825-y. 22797525. 2012ArMic.194..949M. 18532277. Submitted manuscript.
• Weinitschke. S. Denger. K. Cook. AM. Smits. TH. The DUF81 protein TauE in Cupriavidus necator H16, a sulfite exporter in the metabolism of C2 sulfonates.. Microbiology. September 2007. 153. 9. 3055–60. 17768248. 10.1099/mic.0.2007/009845-0. free.
• Gristwood. T. McNeil. MB. Clulow. JS. Salmond. GP. Fineran. PC. PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules.. Journal of Bacteriology. March 2011. 193. 5. 1076–85. 10.1128/JB.00352-10. 21183667. 3067589.

Notes and References

1. Weinitschke. S. Denger. K. Cook. AM. Smits. TH. The DUF81 protein TauE in Cupriavidus necator H16, a sulfite exporter in the metabolism of C2 sulfonates.. Microbiology. September 2007. 153. 9. 3055–60. 17768248. 10.1099/mic.0.2007/009845-0. free.
2. Mayer. J. Denger. K. Hollemeyer. K. Schleheck. D. Cook. AM. (R)-Cysteate-nitrogen assimilation by Cupriavidus necator H16 with excretion of 3-sulfolactate: a patchwork pathway.. Archives of Microbiology. November 2012. 194. 11. 949–57. 10.1007/s00203-012-0825-y. 22797525. 2012ArMic.194..949M. 18532277. Submitted manuscript.
3. Krejcík. Z. Denger. K. Weinitschke. S. Hollemeyer. K. Paces. V. Cook. AM. Smits. TH. Sulfoacetate released during the assimilation of taurine-nitrogen by Neptuniibacter caesariensis: purification of sulfoacetaldehyde dehydrogenase.. Archives of Microbiology. August 2008. 190. 2. 159–68. 10.1007/s00203-008-0386-2. 18506422. 2008ArMic.190..159K. 16756687. Submitted manuscript.
4. Mampel. J. Maier. E. Tralau. T. Ruff. J. Benz. R. Cook. AM. A novel outer-membrane anion channel (porin) as part of a putatively two-component transport system for 4-toluenesulphonate in Comamonas testosteroni T-2.. Biochemical Journal. October 1, 2004. 383. 1. 91–9. 15176949. 10.1042/bj20040652. 1134047.
5. Web site: Saier. MH Jr.. 2.A.102. The 4-Toluene Sulfonate Uptake Permease (TSUP) Family. Transporter Classification Database. Saier Lab Bioinformatics Group.