TSTA3 explained

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.^{[1] [2] [3] [4]}

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.

Further reading

• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Roos C, Kolmer M, Mattila P, Renkonen R . Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism . J. Biol. Chem. . 277 . 5 . 3168–75 . 2002 . 11698403 . 10.1074/jbc.M107927200 . free .
• Sullivan FX, Kumar R, Kriz R, etal . Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro . J. Biol. Chem. . 273 . 14 . 8193–202 . 1998 . 9525924 . 10.1074/jbc.273.14.8193 . free .
• Tonetti M, Sturla L, Bisso A, etal . Synthesis of GDP-L-fucose by the human FX protein . J. Biol. Chem. . 271 . 44 . 27274–9 . 1996 . 8910301 . 10.1074/jbc.271.44.27274 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human GDP-L-fucose synthase

Notes and References

1. Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A . Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B . Blood . 85 . 1 . 264–7 . Feb 1995 . 7803801 . 10.1182/blood.V85.1.264.bloodjournal851264. free .
2. Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T . Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198 . Immunogenetics . 35 . 5 . 316–23 . May 1992 . 1348494 . 10.1007/bf00189894. 9048773 .
3. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative . Chem Biol Interact . 178 . 1–3 . 94–8 . Feb 2009 . 19027726 . 2896744. 10.1016/j.cbi.2008.10.040 .
4. Web site: Entrez Gene: TSTA3 tissue specific transplantation antigen P35B.