TSPYL5 (gene) explained

TSPY like 5 is a protein that in humans is encoded by the TSPYL5 gene.^[1]

Further reading

• Jung Y, Park J, Bang YJ, Kim TY . Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers . Lab. Invest. . 88 . 2 . 153–60 . February 2008 . 18059362 . 10.1038/labinvest.3700706 . free .
• Kim EJ, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC, Kim IG . TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway . Biochem. Biophys. Res. Commun. . 392 . 3 . 448–53 . February 2010 . 20079711 . 10.1016/j.bbrc.2010.01.045 .
• Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R . TSPYL5 suppresses p53 levels and function by physical interaction with USP7 . Nat. Cell Biol. . 13 . 1 . 102–8 . January 2011 . 21170034 . 10.1038/ncb2142 . 288643 .
• Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, Schaid DJ, Nakamura Y, Weinshilboum RM . TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression . Mol. Endocrinol. . 27 . 4 . 657–70 . April 2013 . 23518928 . 3607698 . 10.1210/me.2012-1397 .
• Qiu X, Hu B, Huang Y, Deng Y, Wang X, Zheng F . Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance . Dig. Dis. Sci. . 61 . 1 . 149–57 . January 2016 . 26386860 . 10.1007/s10620-015-3878-3 . 22547345 .
• Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V . Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression . Hum. Mol. Genet. . 25 . 9 . 1714–27 . May 2016 . 26911678 . 4986328 . 10.1093/hmg/ddw043 .
• Lakshmanan I, Salfity S, Seshacharyulu P, Rachagani S, Thomas A, Das S, Majhi PD, Nimmakayala RK, Vengoji R, Lele SM, Ponnusamy MP, Batra SK, Ganti AK . MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53 . Clin. Cancer Res. . 23 . 14 . 3906–3917 . July 2017 . 28196872 . 5511558 . 10.1158/1078-0432.CCR-16-2530 .
• Kumar SR, Bryan JN, Esebua M, Amos-Landgraf J, May TJ . Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma . BMC Cancer . 17 . 1 . 158 . February 2017 . 28235398 . 5326500 . 10.1186/s12885-017-3134-7 . free .
• Shao L, Shen Z, Qian H, Zhou S, Chen Y . Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5 . DNA Cell Biol. . 36 . 12 . 1108–1116 . December 2017 . 28972400 . 10.1089/dna.2017.3904 .

Notes and References

1. Web site: Entrez Gene: TSPY like 5. 2018-09-06.