TSPAN8 explained

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.^{[1] [2]}

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.

Clinical significance

Overall survival of ovarian cancer patients was effectively predicted by TSPAN8.^[3]

Further reading

• Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye . Journal of Cell Science . 114 . Pt 23 . 4143–51 . December 2001 . 10.1242/jcs.114.23.4143 . 11739647 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Gwynn B, Eicher EM, Peters LL . Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome . Genomics . 35 . 2 . 389–91 . July 1996 . 8661157 . 10.1006/geno.1996.0375 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E . Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions . The Biochemical Journal . 340 (Pt 1) . Pt 1 . 103–11 . May 1999 . 10229664 . 1220227 . 10.1042/0264-6021:3400103 .
• Kanetaka K, Sakamoto M, Yamamoto Y, Yamasaki S, Lanza F, Kanematsu T, Hirohashi S . Overexpression of tetraspanin CO-029 in hepatocellular carcinoma . Journal of Hepatology . 35 . 5 . 637–42 . November 2001 . 11690710 . 10.1016/S0168-8278(01)00183-0 .
• Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW . Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization . Hepatology . 38 . 3 . 577–88 . September 2003 . 12939584 . 10.1053/jhep.2003.50376 . 46013740 . free .
• Kuhn S, Koch M, Nübel T, Ladwein M, Antolovic D, Klingbeil P, Hildebrand D, Moldenhauer G, Langbein L, Franke WW, Weitz J, Zöller M . A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression . Molecular Cancer Research . 5 . 6 . 553–67 . June 2007 . 17579117 . 10.1158/1541-7786.MCR-06-0384 . free .

Notes and References

1. Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ . Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens . Proceedings of the National Academy of Sciences of the United States of America . 87 . 17 . 6833–7 . September 1990 . 2395876 . 54632 . 10.1073/pnas.87.17.6833 . 1990PNAS...87.6833S . free .
2. Web site: Entrez Gene: TSPAN8 tetraspanin 8.
3. Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B . Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples . International Journal of Cancer . 131 . 1 . 95–105 . July 2012 . 21858809 . 10.1002/ijc.26364 . 205944534 . free .