TSPAN4 explained

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.^{[1] [2]}

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions

TSPAN4 has been shown to interact with CD9, ITGA6,^[1] CD29,^[1] CD49c^[1] and CD81.^[1]

Further reading

• Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye. . J. Cell Sci. . 114 . Pt 23 . 4143–51 . 2002 . 10.1242/jcs.114.23.4143 . 11739647 .
• Todd SC, Doctor VS, Levy S . Sequences and expression of six new members of the tetraspanin/TM4SF family. . Biochim. Biophys. Acta . 1399 . 1 . 101–4 . 1998 . 9714763 . 10.1016/s0167-4781(98)00087-6. free .
• Serru V, Le Naour F, Billard M, etal . Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. . 340 . Biochem. J. . 1. 103–11 . 1999 . 10229664 . 10.1042/0264-6021:3400103 . 1220227 .
• Yauch RL, Kazarov AR, Desai B, etal . Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151. . J. Biol. Chem. . 275 . 13 . 9230–8 . 2000 . 10734060 . 10.1074/jbc.275.13.9230 . free .
• Lozahic S, Christiansen D, Manié S, etal . CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans. . Eur. J. Immunol. . 30 . 3 . 900–7 . 2000 . 10741407 . 10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X . free .
• Suzuki H, Fukunishi Y, Kagawa I, etal . Protein-protein interaction panel using mouse full-length cDNAs. . Genome Res. . 11 . 10 . 1758–65 . 2001 . 11591653 . 10.1101/gr.180101 . 311163 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Clark AG, Glanowski S, Nielsen R, etal . Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios. . Science . 302 . 5652 . 1960–3 . 2003 . 14671302 . 10.1126/science.1088821 . 2003Sci...302.1960C . 6682593 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Oh JH, Yang JO, Hahn Y, etal . Transcriptome analysis of human gastric cancer. . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . 69278 .

Notes and References

1. Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME . NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins . J Biol Chem . 272 . 46 . 29181–9 . Dec 1997 . 9360996 . 10.1074/jbc.272.46.29181 . free .
2. Web site: Entrez Gene: TSPAN4 tetraspanin 4.