TSPAN32 explained

Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.^{[1] [2] [3]}

Function

This gene is described as a member of the tetraspanin superfamily whose expression is confined to hematopoietic tissues.

Clinical significance

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.

Further reading

• Koi M, Johnson LA, Kalikin LM, Little PF, Nakamura Y, Feinberg AP . Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. . Science . 260 . 5106 . 361–4 . 1993 . 8469989 . 10.1126/science.8469989 . 1993Sci...260..361K . 15041763 .
• Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP . A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. . Genomics . 46 . 1 . 9–17 . 1998 . 9403053 . 10.1006/geno.1997.4981 . free .
• Paulsen M, El-Maarri O, Engemann S, Strödicke M, Franck O, Davies K, Reinhardt R, Reik W, Walter J . Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. . Hum. Mol. Genet. . 9 . 12 . 1829–41 . 2000 . 10915772 . 10.1093/hmg/9.12.1829 . free .
• Robb L, Tarrant J, Groom J, Ibrahim M, Li R, Borobakas B, Wright MD . Molecular characterisation of mouse and human TSSC6: evidence that TSSC6 is a genuine member of the tetraspanin superfamily and is expressed specifically in haematopoietic organs. . Biochim. Biophys. Acta . 1522 . 1 . 31–41 . 2001 . 11718897 . 10.1016/s0167-4781(01)00306-2 .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance. . Genome Biol. . 5 . 2 . R8 . 2005 . 14759258 . 395752 . 10.1186/gb-2004-5-2-r8 . free .

Notes and References

1. Lee MP, Brandenburg S, Landes GM, Adams M, Miller G, Feinberg AP . Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting . Hum Mol Genet . 8 . 4 . 683–90 . Apr 1999 . 10072438 . 10.1093/hmg/8.4.683 . free .
2. Nicholson RH, Pantano S, Eliason JF, Galy A, Weiler S, Kaplan J, Hughes MR, Ko MS . Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7 . Genomics . 68 . 1 . 13–21 . Sep 2000 . 10950922 . 10.1006/geno.2000.6277 .
3. Web site: Entrez Gene: TSPAN32 tetraspanin 32.